44906

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1275648..1277401 Replicon chromosome
Accession NZ_CP004024
Organism Burkholderia pseudomallei MSHR511

Toxin (Protein)


Gene name hipA Uniprot ID B1H781
Locus tag BBQ_RS23490 Protein ID WP_004525276.1
Coordinates 1275648..1277000 (-) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BBQ_RS23495 Protein ID WP_038730352.1
Coordinates 1276997..1277401 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBQ_RS23470 1271966..1272307 - 342 WP_004539420.1 hypothetical protein -
BBQ_RS23475 1272584..1273537 - 954 WP_004187785.1 agmatinase -
BBQ_RS23480 1273704..1274618 + 915 WP_004198844.1 LysR family transcriptional regulator -
BBQ_RS23485 1275039..1275491 + 453 WP_041199101.1 hypothetical protein -
BBQ_RS23490 1275648..1277000 - 1353 WP_004525276.1 type II toxin-antitoxin system HipA family toxin Toxin
BBQ_RS23495 1276997..1277401 - 405 WP_038730352.1 helix-turn-helix domain-containing protein Antitoxin
BBQ_RS40375 1277739..1278002 - 264 WP_004199789.1 hypothetical protein -
BBQ_RS23510 1278467..1280863 + 2397 WP_051430414.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -
BBQ_RS23515 1280868..1282397 + 1530 WP_041188330.1 cellulase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49790.80 Da        Isoelectric Point: 9.8300

>T44906 WP_004525276.1 NZ_CP004024:c1277000-1275648 [Burkholderia pseudomallei MSHR511]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTAGVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Download         Length: 1353 bp

>T44906 NZ_CP004024:c1277000-1275648 [Burkholderia pseudomallei MSHR511]
GTGAGCGCCCGCCGCGCACGCGCGACGCGCCTGCACCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCACGCGCG
CGACGGCGAGCGCCTTGTCTACTTCGACGAATGGATCGGCGATCCGCAAGGCCGGCCGCTGTCGCTGTCGCTGCCGTTCA
CGCCGGGCAACCAGCCGTATCGCGGTCGGCTCGTCAGCGATTATTTCGACAACCTGCTGCCCGACAGCGAGCCGATCCGC
CGGCGAATCGCGATGCGCTACCGCACGGGCGGCACGTCCGCGTTCGCGCTGCTCGCGACGCTCGGCCGCGATTGCGTCGG
CGCGCTGCAGATGCTGCCGCCCGACGAAGCGCCGGACGACATCGAACGCATCCGCGGCCACGCGCTCGCCGACGCGGACA
TCGCGCGCCTGCTGCGCGAAGTCACGTCCGCGCCGCAGGCCGGCCGGCACGCGCCGCTCGACGATCTGCGCCTGTCGATC
GCCGGCGCGCAGGAGAAGACCGCGCTGCTGCGCCATCGCGGCCGCTGGCTGCTGCCCGAAGGGAGCACGCCGACCACGCA
CATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGTGCG
CGCGGATCGTCGCCGCGTACGGGTTGCCCGTCGCGCGCTGCGACATCGCGCAGTTCGACGATCAGAAAGCGCTCGTCGTC
GAGCGCTTCGACCGCCGGCCGTCGCGCGACGCGCGCTGGCTCCTGCGGCTGCCGCAGGAAGACATGTGCCAGGCAACCGG
CACGTCCGCGCTCGACAAATATCAGGCCGACGGCGGCCCCGGCATCGAGACGATCATGGAAGTGCTCGCCGGCTCCGAAC
ACGCGCGGGACGACCGCCGCGCGTTCTTCGCGGCGCAGATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAG
AACTTCAGCATCGCGCACCTGCCCGGCAACCGCTACCGTTCGACGCCGCTTTACGACGTGCTGTCCGCGCATCCGGTCAT
CGGCCGGGGCGCGAACCAGTTGCCCGCGCAGCGCGCGCGGCTAGCGATGGGCGTGCGCGGCAAGCACATCCACTATCCGC
TGCACCAGATCCGGCGGCGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCCGCCGACGTCGACGCGCTGATC
GACACGCTGACCGCGCGCACCGCGGGCGTCGTCGACGCGGTGTCGGCGCGGCTGCCGCGCGATTTTCCGCGCGACGTCGC
CGATGCGATCTTCAGCGGAATGCTCGGCCTGAGCGCAAGGCTCGCCGGCGACGCGGCCGCGCGCGCGCCATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14253.55 Da        Isoelectric Point: 11.7233

>AT44906 WP_038730352.1 NZ_CP004024:c1277401-1276997 [Burkholderia pseudomallei MSHR511]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEAAKTAAGARAGARRAVPPASAPAPSAAGRAPRPARKRAAPKKREDW

Download         Length: 405 bp

>AT44906 NZ_CP004024:c1277401-1276997 [Burkholderia pseudomallei MSHR511]
ATGGCCATCCTCATCGAGCACGAGATCAAGACACTCGGCCAACTGCGGCCGATTCTGCGCGGCTTCCGCAAATCGGCCGG
ATTGACGCAGGCGATGCTCGCGAGCCGCCTCGGCGTCACGCAGCAGACCTACGCGCAGTTCGAGGCGAACCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGCGCTCGACATCGAACTCACGCTCACGCTCACGCAGGTCTACGCCGCG
CCCGCGGGCAAGGACAAGGGCGAGGCTGCGAAGACGGCCGCAGGCGCGCGCGCGGGCGCGCGACGTGCCGTGCCGCCCGC
GTCCGCGCCCGCTCCGAGCGCCGCCGGGCGCGCGCCCCGCCCCGCCCGCAAGCGCGCCGCCCCGAAAAAGCGGGAGGACT
GGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K3EM91

Antitoxin

Source ID Structure

References