44892

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5229070..5229695 Replicon chromosome
Accession NZ_CP003999
Organism Klebsiella pneumoniae subsp. pneumoniae Kp13

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag KP13_RS26590 Protein ID WP_002882817.1
Coordinates 5229070..5229453 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag KP13_RS26595 Protein ID WP_004150355.1
Coordinates 5229453..5229695 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP13_RS26575 5226436..5227338 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
KP13_RS26580 5227335..5227970 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
KP13_RS26585 5227967..5228896 + 930 WP_025368581.1 formate dehydrogenase accessory protein FdhE -
KP13_RS26590 5229070..5229453 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
KP13_RS26595 5229453..5229695 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
KP13_RS26600 5229900..5230817 + 918 WP_025368582.1 alpha/beta hydrolase -
KP13_RS26605 5230832..5231773 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
KP13_RS26610 5231818..5232255 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
KP13_RS26615 5232252..5233112 - 861 WP_004146232.1 virulence factor BrkB family protein -
KP13_RS26620 5233106..5233705 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T44892 WP_002882817.1 NZ_CP003999:c5229453-5229070 [Klebsiella pneumoniae subsp. pneumoniae Kp13]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T44892 NZ_CP003999:c5229453-5229070 [Klebsiella pneumoniae subsp. pneumoniae Kp13]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT44892 WP_004150355.1 NZ_CP003999:c5229695-5229453 [Klebsiella pneumoniae subsp. pneumoniae Kp13]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT44892 NZ_CP003999:c5229695-5229453 [Klebsiella pneumoniae subsp. pneumoniae Kp13]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References