Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3874755..3875280 Replicon chromosome
Accession NZ_CP003987
Organism Streptomyces sp. 769

Toxin (Protein)


Gene name relE Uniprot ID A0A1T4SXS3
Locus tag GZL_RS16320 Protein ID WP_032763468.1
Coordinates 3875017..3875280 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A8EK65
Locus tag GZL_RS16315 Protein ID WP_039633133.1
Coordinates 3874755..3875024 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZL_RS16300 3870691..3871440 - 750 WP_039633129.1 GntR family transcriptional regulator -
GZL_RS16305 3871659..3872420 + 762 WP_039640898.1 PIG-L family deacetylase -
GZL_RS16310 3872657..3874333 - 1677 WP_039633131.1 hypothetical protein -
GZL_RS16315 3874755..3875024 + 270 WP_039633133.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GZL_RS16320 3875017..3875280 + 264 WP_032763468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZL_RS16325 3875416..3876504 - 1089 WP_039633137.1 redox-regulated ATPase YchF -
GZL_RS16335 3877500..3878444 - 945 WP_039633139.1 ROK family protein -
GZL_RS16340 3878518..3879519 - 1002 WP_078875757.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-59)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10056.49 Da        Isoelectric Point: 8.5041

>T44873 WP_032763468.1 NZ_CP003987:3875017-3875280 [Streptomyces sp. 769]
VSEYRTVFRPEAQAELRKVPRDMALRILAKLTELESDPLGFNTTALVSQPDRRRLRVGDYRVIYTIDNGELVVWVVHVGH
RSTVYDT

Download         Length: 264 bp

>T44873 NZ_CP003987:3875017-3875280 [Streptomyces sp. 769]
GTGAGTGAGTACCGCACCGTCTTCCGGCCCGAGGCTCAGGCCGAACTCCGCAAGGTGCCGCGAGACATGGCCCTCCGCAT
TCTGGCCAAGTTGACCGAGCTGGAGAGTGACCCTCTGGGGTTCAACACCACCGCCCTCGTCTCCCAACCCGACCGCCGCC
GCCTACGCGTGGGCGACTACCGCGTGATCTACACGATCGACAACGGCGAGCTGGTGGTGTGGGTCGTGCATGTCGGGCAT
CGCTCCACTGTGTACGACACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10275.71 Da        Isoelectric Point: 4.6168

>AT44873 WP_039633133.1 NZ_CP003987:3874755-3875024 [Streptomyces sp. 769]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIDVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARSE

Download         Length: 270 bp

>AT44873 NZ_CP003987:3874755-3875024 [Streptomyces sp. 769]
ATGACACAGCCGCTGCCCATAGAGTCCATCCGCGATGTCCGGGCGCACCTGGCCGAGGTCGTGGAACGAGCCGACCGCGA
CGACGTGCCGACGGTAATCACGCGCCGAGGCAAGGAGGTGGCTGCCGTGGTGTCCATCGACGTGCTCCGGAAATACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAATCCGGCGCCCGGTATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCAGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1T4SXS3

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8EK65

References