Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 725413..726068 Replicon chromosome
Accession NZ_CP003974
Organism Neisseria gonorrhoeae NG-k51.05

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag T556_RS04495 Protein ID WP_003691083.1
Coordinates 725649..726068 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag T556_RS04490 Protein ID WP_003688410.1
Coordinates 725413..725649 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
T556_RS04445 720547..720834 + 288 WP_003688407.1 hypothetical protein -
T556_RS04450 720906..722072 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
T556_RS04455 722083..722973 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
T556_RS04465 723356..723742 - 387 Protein_751 IS110 family transposase -
T556_RS04475 723954..724382 + 429 WP_003701165.1 helix-turn-helix domain-containing protein -
T556_RS04480 724387..724965 + 579 WP_003688041.1 IS3 family transposase -
T556_RS04485 725010..725207 + 198 WP_033910354.1 IS3 family transposase -
T556_RS04490 725413..725649 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
T556_RS04495 725649..726068 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
T556_RS04500 726217..727671 - 1455 WP_003701282.1 iron-sulfur cluster-binding protein -
T556_RS04505 727668..728369 - 702 WP_003688414.1 lactate utilization protein C -
T556_RS04510 728366..729145 - 780 WP_041421436.1 (Fe-S)-binding protein -
T556_RS04515 729293..730834 + 1542 WP_003697015.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T44871 WP_003691083.1 NZ_CP003974:725649-726068 [Neisseria gonorrhoeae NG-k51.05]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T44871 NZ_CP003974:725649-726068 [Neisseria gonorrhoeae NG-k51.05]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT44871 WP_003688410.1 NZ_CP003974:725413-725649 [Neisseria gonorrhoeae NG-k51.05]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT44871 NZ_CP003974:725413-725649 [Neisseria gonorrhoeae NG-k51.05]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References