Detailed information of TA system TA044870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4295116..4295774
• Replicon: chromosome
• Accession: NZ_CP003915
• Organism: Advenella mimigardefordensis DPN7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MIM_RS19725
• Protein ID: WP_025374487.1
• Coordinates: 4295116..4295514 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MIM_RS19730
• Protein ID: WP_187329590.1
• Coordinates: 4295520..4295774 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIM_RS22285	4291553..4294927	-	3375	WP_025374486.1	toll/interleukin-1 receptor domain-containing protein	-
MIM_RS19725	4295116..4295514	-	399	WP_025374487.1	type II toxin-antitoxin system VapC family toxin	Toxin
MIM_RS19730	4295520..4295774	-	255	WP_187329590.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MIM_RS19735	4295868..4296296	-	429	WP_042070615.1	VOC family protein	-
MIM_RS19740	4296463..4298754	-	2292	WP_025374489.1	NADP-dependent malic enzyme	-
MIM_RS19745	4298920..4299852	+	933	WP_025374490.1	LysR family transcriptional regulator	-
MIM_RS19750	4299991..4300323	-	333	WP_025374491.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

• SpoVT-AbrB domain (10-54)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14701.21 Da
• Isoelectric Point: 8.1609

>T44870 WP_025374487.1 NZ_CP003915:c4295514-4295116 [Advenella mimigardefordensis DPN7]
MKRYMLDTNMVSLALKNHPLVVSRLTTVPMASLCISVITQAELLFGLAKRPQSKSLHTLIHAFLTHIEVLHWRSDSAASY
GKLHATLEKQGRSLGALDMLIAAHAVSEQAVLVTNDRAFMQLPHMVVEDWSE

Nucleotide

• Length: 399 bp

>T44870 NZ_CP003915:c4295514-4295116 [Advenella mimigardefordensis DPN7]
ATGAAACGTTACATGTTAGATACCAATATGGTGAGCCTGGCATTGAAGAATCATCCTTTAGTCGTGTCCAGGTTAACCAC
CGTTCCGATGGCATCTTTGTGCATCTCGGTCATCACGCAAGCGGAATTATTGTTTGGTCTTGCTAAACGACCGCAATCGA
AATCGCTGCATACGCTGATACATGCGTTTTTAACGCATATTGAGGTACTTCACTGGCGTAGTGATTCGGCCGCGAGTTAT
GGAAAATTGCACGCAACGCTGGAAAAACAGGGCAGGAGTCTGGGTGCGCTGGACATGCTTATTGCTGCACATGCAGTCAG
TGAGCAAGCTGTATTGGTAACCAATGACCGGGCATTTATGCAGTTGCCTCACATGGTGGTTGAGGACTGGAGCGAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9517.67 Da
• Isoelectric Point: 5.8296

>AT44870 WP_187329590.1 NZ_CP003915:c4295774-4295520 [Advenella mimigardefordensis DPN7]
MTQIAKLFANGRSQAVRLPAAFRFEGTEVFIRKDERTGDVILSQRPPTWDAFVQLVGKHPAPQDFLSKDERGASEQQDRD
PFAE

Nucleotide

• Length: 255 bp

>AT44870 NZ_CP003915:c4295774-4295520 [Advenella mimigardefordensis DPN7]
ATGACGCAAATTGCCAAATTATTTGCCAATGGCCGCAGTCAGGCGGTGCGGCTGCCTGCCGCCTTCCGGTTCGAAGGAAC
GGAAGTCTTTATTCGGAAAGATGAAAGAACGGGGGACGTGATTTTGTCTCAGAGGCCACCCACATGGGATGCATTTGTAC
AGTTGGTGGGTAAACATCCGGCCCCCCAGGACTTTCTCTCAAAAGACGAGCGTGGTGCCAGTGAGCAGCAGGATCGTGAC
CCCTTTGCCGAGTAA