Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2998774..2999245 Replicon chromosome
Accession NZ_CP003915
Organism Advenella mimigardefordensis DPN7

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MIM_RS13775 Protein ID WP_025373342.1
Coordinates 2999042..2999245 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MIM_RS13770 Protein ID WP_042070345.1
Coordinates 2998774..2999061 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIM_RS13740 2994244..2994555 + 312 WP_025373335.1 hypothetical protein -
MIM_RS13745 2994926..2995657 + 732 WP_025373336.1 UTRA domain-containing protein -
MIM_RS13750 2995672..2996532 + 861 WP_025373337.1 sulfite exporter TauE/SafE family protein -
MIM_RS13755 2996529..2996846 + 318 WP_025373338.1 DUF1634 domain-containing protein -
MIM_RS23330 2996961..2997104 - 144 WP_169733360.1 hypothetical protein -
MIM_RS13760 2997434..2998048 + 615 WP_025373339.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
MIM_RS13765 2998342..2998617 - 276 WP_025373340.1 hypothetical protein -
MIM_RS13770 2998774..2999061 - 288 WP_042070345.1 putative addiction module antidote protein Antitoxin
MIM_RS13775 2999042..2999245 - 204 WP_025373342.1 hypothetical protein Toxin
MIM_RS13785 2999747..3000232 - 486 WP_025373343.1 Cys-tRNA(Pro) deacylase -
MIM_RS13790 3000302..3001219 - 918 WP_025373344.1 site-specific tyrosine recombinase XerD -
MIM_RS13795 3001326..3002231 + 906 WP_025373345.1 AEC family transporter -
MIM_RS13800 3002330..3002890 + 561 WP_025373346.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
MIM_RS13805 3002842..3004170 + 1329 WP_025373347.1 N-acetylmuramoyl-L-alanine amidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-58)

Antitoxin

Uncharacterized protein HI1420

(4-92)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7737.93 Da        Isoelectric Point: 9.6003

>T44869 WP_025373342.1 NZ_CP003915:c2999245-2999042 [Advenella mimigardefordensis DPN7]
MHVEPVGEGVSELKIHYGPGYRVYFQQRGNVLILLLCGGDKKTQRRDIVEAKQIAKEWSAQHDRKIF

Download         Length: 204 bp

>T44869 NZ_CP003915:c2999245-2999042 [Advenella mimigardefordensis DPN7]
ATGCACGTTGAGCCGGTGGGTGAGGGTGTAAGTGAGCTGAAAATTCACTATGGACCCGGTTACAGGGTTTATTTTCAGCA
GAGGGGAAACGTCCTAATCCTGCTTTTGTGTGGCGGCGATAAGAAAACGCAGCGCCGCGACATAGTTGAAGCAAAGCAAA
TCGCCAAAGAATGGAGCGCACAACATGATCGAAAAATTTTCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10256.62 Da        Isoelectric Point: 4.5680

>AT44869 WP_042070345.1 NZ_CP003915:c2999061-2998774 [Advenella mimigardefordensis DPN7]
MIEKFSKYDPANVLETDEDIAFFMADALETGDSGYIANALGIVARAKGMAQIAEETGLSREQLYRSFSERGNPTLKTTMA
VLNALGVQLTAKHAA

Download         Length: 288 bp

>AT44869 NZ_CP003915:c2999061-2998774 [Advenella mimigardefordensis DPN7]
ATGATCGAAAAATTTTCTAAATACGATCCAGCCAATGTGTTGGAAACCGACGAAGATATTGCTTTTTTTATGGCCGATGC
GCTGGAAACCGGGGACTCCGGCTATATTGCCAACGCGCTTGGCATAGTGGCCAGGGCTAAAGGCATGGCGCAGATTGCAG
AGGAAACCGGTCTGTCTCGTGAACAGCTCTATCGTTCATTTAGTGAACGAGGCAACCCCACGCTCAAAACCACTATGGCG
GTTTTGAATGCACTTGGTGTTCAACTCACAGCCAAGCACGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References