Detailed information of TA system TA044868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 880594..881204
• Replicon: chromosome
• Accession: NZ_CP003915
• Organism: Advenella mimigardefordensis DPN7

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: MIM_RS04050
• Protein ID: WP_025371485.1
• Coordinates: 880594..880890 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MIM_RS04055
• Protein ID: WP_025371486.1
• Coordinates: 880896..881204 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIM_RS04025	876317..877642	+	1326	WP_025371480.1	hypothetical protein	-
MIM_RS04030	877763..878278	-	516	WP_025371481.1	thermonuclease family protein	-
MIM_RS04035	878482..879108	+	627	WP_025371482.1	hypothetical protein	-
MIM_RS04040	879198..879437	+	240	WP_025371483.1	hypothetical protein	-
MIM_RS04045	880006..880497	+	492	WP_187329599.1	JAB domain-containing protein	-
MIM_RS04050	880594..880890	+	297	WP_025371485.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MIM_RS04055	880896..881204	+	309	WP_025371486.1	putative addiction module antidote protein	Antitoxin
MIM_RS04060	881805..882104	+	300	WP_025371487.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
MIM_RS04065	882091..882377	+	287	Protein_810	type II toxin-antitoxin system RelE/ParE family toxin	-
MIM_RS04070	882806..884647	+	1842	WP_025371488.1	ABC transporter ATP-binding protein/permease	-
MIM_RS04075	884848..885765	-	918	WP_025371489.1	dihydrodipicolinate synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	865220..882104	16884

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-91)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11143.92 Da
• Isoelectric Point: 10.6937

>T44868 WP_025371485.1 NZ_CP003915:880594-880890 [Advenella mimigardefordensis DPN7]
MIEVIKSDVFDRWLNSLKDRQARARVQTRIRRLSLGNPGDVKPVGGGVSEMRIDYGPGYRLYYMQRGPVVVVLLCGGDKR
TQSRDIAHAKVIATQWKE

Nucleotide

• Length: 297 bp

>T44868 NZ_CP003915:880594-880890 [Advenella mimigardefordensis DPN7]
ATGATCGAAGTTATTAAATCCGATGTTTTCGACCGCTGGCTTAACTCGCTGAAGGATCGCCAAGCACGGGCAAGGGTACA
AACCCGCATTCGGCGGCTCAGCCTGGGTAATCCTGGCGATGTTAAGCCAGTCGGTGGGGGTGTTTCCGAGATGAGAATCG
ATTATGGCCCTGGGTATCGCCTATATTACATGCAGCGCGGTCCGGTGGTTGTGGTGTTGCTCTGTGGCGGCGACAAGCGT
ACTCAAAGCCGTGACATTGCCCACGCAAAGGTAATAGCCACACAATGGAAGGAGTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 10852.22 Da
• Isoelectric Point: 4.5895

>AT44868 WP_025371486.1 NZ_CP003915:880896-881204 [Advenella mimigardefordensis DPN7]
MDVKFSRYDTADYLKSEEDIVAYLDAVMEDGEPGLIAAALGDVARARNLSQLARDVGMSRQGLDKALSGEGNPSLATVLK
VAQALGLRLSWKVDNASHSTGV

Nucleotide

• Length: 309 bp

>AT44868 NZ_CP003915:880896-881204 [Advenella mimigardefordensis DPN7]
ATGGACGTTAAATTTAGCCGCTACGACACGGCTGATTATCTCAAGAGCGAAGAAGATATCGTTGCCTACCTTGATGCCGT
AATGGAAGACGGAGAACCCGGCCTAATTGCGGCTGCGCTTGGTGATGTCGCACGAGCCAGAAATTTGAGTCAACTTGCGC
GTGATGTCGGTATGAGCCGTCAGGGGCTAGATAAGGCCCTTTCTGGCGAAGGCAATCCTAGCCTTGCGACAGTGTTAAAA
GTTGCTCAGGCACTTGGTTTACGCTTGTCGTGGAAAGTGGATAATGCCAGCCATTCCACTGGCGTATAA