Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 424309..425426 Replicon chromosome
Accession NZ_CP003915
Organism Advenella mimigardefordensis DPN7

Toxin (Protein)


Gene name - Uniprot ID W0P6H4
Locus tag MIM_RS01910 Protein ID WP_025371073.1
Coordinates 424309..425055 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W0PAM4
Locus tag MIM_RS01915 Protein ID WP_025371074.1
Coordinates 425055..425426 (-) Length 124 a.a.

Genomic Context

MIM_RS01900MIM_RS01925MIM_RS01930MIM_RS01935MIM_RS01905MIM_RS01910MIM_RS01915MIM_RS01940
Location: 421027..422697 (1671 bp)
Type: Others
Protein ID: WP_025371071.1
Location: 425806..426453 (648 bp)
Type: Others
Protein ID: WP_025371075.1
Location: 426564..427415 (852 bp)
Type: Others
Protein ID: WP_084459068.1
Location: 427405..427902 (498 bp)
Type: Others
Protein ID: WP_025371077.1
Location: 422858..424015 (1158 bp)
Type: Others
Protein ID: WP_025371072.1
Location: 424309..425055 (747 bp)
Type: Toxin
Protein ID: WP_025371073.1
Location: 425055..425426 (372 bp)
Type: Antitoxin
Protein ID: WP_025371074.1
Location: 427945..429339 (1395 bp)
Type: Others
Protein ID: WP_144084721.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MIM_RS01900421027..422697+1671WP_025371071.1aromatic amino acid lyase-
MIM_RS01905422858..424015-1158WP_025371072.1Na+/H+ antiporter NhaA-
MIM_RS01910424309..425055-747WP_025371073.1RES family NAD+ phosphorylaseToxin
MIM_RS01915425055..425426-372WP_025371074.1XRE family transcriptional regulatorAntitoxin
MIM_RS01925425806..426453+648WP_025371075.1LemA family protein-
MIM_RS01930426564..427415+852WP_084459068.1YgcG family protein-
MIM_RS01935427405..427902+498WP_025371077.1TPM domain-containing protein-
MIM_RS01940427945..429339-1395WP_144084721.1GTPase/DUF3482 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(62-205)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(70-121)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 28170.10 Da        Isoelectric Point: 7.7808

>T44867 WP_025371073.1 NZ_CP003915:c425055-424309 [Advenella mimigardefordensis DPN7]
MIWQACNGPEHIRQIDGRLHRLVESQEQIATLGYVDTLEEQALLEQMLDQAKPVSQPDCEPLHYLLKTPFRYPPLKWGSR
FGRVHERSLFYGGRNIGAVLAESAFYRFVFWHSMDGMPVKDRIRSEHTLFSVRYGTEKGIQLQAPPFNRYQAALTNPVNY
QAAQQIGSAMRAADVEAFEYCSARDPEHGLCVALFSPAAFRQKKPQETSQWFGELSADRVSFTQLRSGKVMTYGIGLFLV
DGVLPRPA

Download         Length: 747 bp

>T44867 NZ_CP003915:c425055-424309 [Advenella mimigardefordensis DPN7]
ATGATCTGGCAAGCCTGCAACGGCCCTGAACATATCCGGCAGATCGATGGCAGGCTGCACCGGCTCGTGGAAAGCCAGGA
GCAAATTGCCACACTCGGCTATGTGGACACGCTGGAAGAACAGGCCCTGCTGGAACAGATGCTGGACCAGGCCAAGCCCG
TTTCGCAACCCGATTGCGAACCGCTGCATTATCTGCTCAAAACGCCGTTCCGCTATCCGCCGCTCAAATGGGGTTCACGC
TTCGGGCGGGTGCATGAACGCAGCCTGTTCTATGGAGGCAGAAATATCGGTGCGGTGCTGGCCGAAAGCGCTTTCTATCG
TTTCGTATTCTGGCACTCGATGGACGGCATGCCGGTCAAGGACCGGATCCGCAGCGAGCATACGCTTTTTTCGGTGCGCT
ACGGCACAGAAAAAGGGATACAACTTCAGGCGCCACCGTTTAACCGGTATCAGGCCGCGTTAACCAATCCGGTCAATTAC
CAGGCAGCCCAGCAAATAGGCAGCGCCATGCGCGCCGCCGATGTCGAAGCCTTCGAATACTGCTCGGCCCGCGATCCTGA
ACATGGCCTGTGCGTCGCCCTCTTTTCCCCTGCAGCATTCAGGCAAAAGAAACCCCAGGAGACCAGTCAGTGGTTTGGAG
AGCTCAGTGCAGATCGGGTCTCTTTTACACAACTGCGCTCGGGCAAAGTCATGACCTATGGCATCGGCTTATTTCTGGTC
GATGGCGTGTTGCCCAGGCCGGCCTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13220.48 Da        Isoelectric Point: 10.7588

>AT44867 WP_025371074.1 NZ_CP003915:c425426-425055 [Advenella mimigardefordensis DPN7]
MTALQQPKPATEAVLAKAVLRAAEQLGLKQAELAAVLGLHRTAISRLKSTPSLDPDSKQGELALLLLRLARALFALTGGD
QEWIRHFMRTPNNITGGIPAAQIETIQGMTTVLQFVDAIRGKV

Download         Length: 372 bp

>AT44867 NZ_CP003915:c425426-425055 [Advenella mimigardefordensis DPN7]
ATGACCGCATTGCAACAACCCAAACCCGCAACTGAAGCCGTTCTGGCCAAAGCGGTTCTGCGCGCTGCCGAGCAACTCGG
CCTGAAGCAGGCGGAACTGGCTGCCGTGCTGGGGCTGCACCGCACCGCCATCAGCCGCCTCAAATCCACCCCGTCACTGG
ACCCTGACAGCAAACAGGGTGAACTGGCCTTGCTGTTGTTGCGTCTTGCCCGTGCCCTCTTTGCCCTCACAGGCGGCGAT
CAGGAATGGATCCGCCACTTCATGCGCACCCCAAACAACATCACCGGCGGCATCCCTGCAGCCCAGATCGAGACCATACA
GGGAATGACAACGGTATTGCAGTTTGTCGATGCCATCCGCGGTAAAGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBW0P6H4

Antitoxin

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Source
ID
Structure
AlphaFold DBW0PAM4

References