44863

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 23734..25457 Replicon plasmid pZM1402302
Accession NZ_CP003717
Organism Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023

Toxin (Protein)


Gene name pmenT Uniprot ID A0A806D022
Locus tag A265_RS09120 Protein ID WP_012954779.1
Coordinates 23734..24378 (+) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID A0A806D8U1
Locus tag A265_RS09125 Protein ID WP_012954778.1
Coordinates 24378..25457 (+) Length 360 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A265_RS09100 19659..20981 + 1323 WP_012954782.1 hypothetical protein -
A265_RS09105 21028..21828 + 801 WP_025420256.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
A265_RS09680 22086..22877 - 792 Protein_17 IS5 family transposase -
A265_RS09120 23734..24378 + 645 WP_012954779.1 DUF4433 domain-containing protein Toxin
A265_RS09125 24378..25457 + 1080 WP_012954778.1 macro domain-containing protein Antitoxin
A265_RS09130 26031..26492 - 462 WP_025420257.1 hypothetical protein -
A265_RS09140 26954..27271 + 318 WP_012954800.1 hypothetical protein -
A265_RS09145 27396..27647 + 252 WP_011078096.1 DUF2312 domain-containing protein -
A265_RS09150 27754..29523 + 1770 WP_023593790.1 helix-turn-helix domain-containing protein -
A265_RS09155 29718..29915 + 198 WP_012954798.1 type II toxin-antitoxin system HicA family toxin -
A265_RS09160 29925..30350 + 426 WP_012954797.1 type II toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..30952 30952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 25002.73 Da        Isoelectric Point: 7.4075

>T44863 WP_012954779.1 NZ_CP003717:23734-24378 [Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023]
MIYKSFNPQKALIWRIVHYSNLPWILDNGLYCGNSKIKSPNWFNIGNPELIQKRADHSVPLPPSGMLNDYIPFYFTPFSP
MLRNISTGWGGIPQLPNEKIIILVSSLHHIADLGLPFLFTDSHAYSPCANYYSNLSDLNQIDWPILQHRDFKRDPDDPAK
FERYQAEALIYQHLPINGLYGIICYTELLKQRIEQEICARNLNLRVYARPEWYF

Download         Length: 645 bp

>T44863 NZ_CP003717:23734-24378 [Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023]
ATGATCTATAAAAGTTTTAATCCACAAAAAGCATTGATATGGCGGATTGTCCATTACAGCAATTTGCCATGGATTTTGGA
TAATGGTCTCTACTGTGGCAATAGTAAGATAAAATCACCCAATTGGTTTAATATTGGCAATCCTGAATTAATCCAAAAAC
GCGCTGACCATTCAGTACCACTGCCTCCATCTGGGATGCTGAATGACTATATACCATTTTACTTCACACCATTTTCTCCG
ATGTTACGGAATATTTCGACAGGCTGGGGCGGTATACCCCAATTACCCAATGAGAAAATTATAATTTTGGTATCCAGTCT
TCACCATATTGCTGATCTGGGATTACCCTTTCTTTTTACAGATAGTCATGCCTACTCTCCGTGCGCTAATTATTACTCTA
ACCTATCTGATCTTAACCAGATCGATTGGCCAATATTGCAACATAGAGATTTTAAACGTGACCCAGATGATCCTGCCAAA
TTTGAGCGATATCAGGCTGAAGCACTTATTTACCAGCATTTGCCGATCAACGGACTATATGGCATTATATGTTATACAGA
ATTGTTGAAACAACGCATTGAGCAAGAGATTTGTGCTCGTAATCTCAATCTTCGGGTTTATGCCCGACCGGAATGGTATT
TCTGA

Antitoxin


Download         Length: 360 a.a.        Molecular weight: 40879.22 Da        Isoelectric Point: 9.1190

>AT44863 WP_012954778.1 NZ_CP003717:24378-25457 [Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023]
MIIFTQGNLLEAKVEALVNTVNTVGVMGKGIALMFKERFHENFRLYSAACKAKEVQIGKMFVTPVYELGETRWIVNFPTK
QHWRNPSRIEWIIKGLQDLRRVLLEKNIKSIAIPPLGAGNGGLSWKDVRGQIELALSDLDIDIFVFEPTSQYQNVAKRTG
VEKLTPARALIAELVRRYWVMGIECSLLEIQKLAWFLQRAIEQYSPDNNPLNLDFQPHKYGPYTHQLNHLLNSLDGSYLH
SDKRISDSDPLDVILFVNKRKDDLQAYLKSEAKPYRQALESAAMLIDGFESPFGMELLATVDWLLTRENIEPNVPALRKG
LRSWRGGEDAALRKDRIFNDRSLGIALDRLTKTSTLAIA

Download         Length: 1080 bp

>AT44863 NZ_CP003717:24378-25457 [Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023]
ATGATTATCTTCACGCAAGGCAACCTACTAGAAGCTAAAGTCGAGGCTCTTGTTAATACCGTTAACACCGTCGGTGTGAT
GGGTAAGGGTATTGCGCTCATGTTTAAAGAGCGCTTCCACGAGAACTTTCGCCTGTATTCTGCTGCGTGTAAGGCTAAGG
AAGTTCAAATCGGTAAGATGTTCGTTACTCCAGTCTATGAACTAGGGGAAACACGCTGGATTGTGAACTTTCCGACTAAA
CAGCATTGGCGTAATCCGTCACGAATAGAATGGATTATAAAAGGCTTACAGGATCTACGGCGTGTCCTGCTCGAAAAGAA
TATAAAATCTATTGCTATTCCTCCTTTGGGTGCTGGCAATGGCGGGCTTTCATGGAAAGATGTTCGTGGACAGATCGAGT
TGGCCTTAAGTGATCTCGATATTGATATTTTTGTGTTTGAGCCGACTAGCCAATACCAAAACGTGGCTAAGAGGACAGGC
GTAGAAAAACTAACGCCTGCGCGCGCCTTAATAGCTGAATTAGTCCGTCGATACTGGGTAATGGGTATAGAATGCAGTTT
GCTTGAAATTCAAAAGCTGGCTTGGTTTCTTCAGAGAGCTATTGAACAGTATTCTCCAGATAATAATCCACTGAATTTAG
ATTTTCAGCCACATAAATATGGTCCTTATACTCATCAGCTAAACCACTTGTTGAATAGTTTAGATGGCAGCTATCTTCAC
TCTGATAAACGTATCAGCGATAGCGACCCGCTGGATGTCATTTTATTTGTTAATAAGCGCAAAGACGATTTACAGGCTTA
TTTGAAAAGTGAGGCCAAGCCTTATAGGCAAGCGTTAGAATCTGCCGCCATGCTCATTGATGGTTTTGAGTCCCCCTTTG
GGATGGAACTGCTGGCTACAGTTGACTGGCTGCTAACTCGCGAAAATATAGAACCTAATGTGCCAGCTTTACGTAAGGGA
TTGCGTTCTTGGCGAGGTGGTGAAGATGCGGCCTTGCGTAAAGATCGAATTTTTAATGACCGATCTTTGGGGATTGCGCT
TGATCGCTTAACTAAAACCTCTACGCTTGCAATAGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806D022

Antitoxin

Source ID Structure
AlphaFold DB A0A806D8U1

References