44860

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 23737..25460 Replicon plasmid pZM1252602
Accession NZ_CP003711
Organism Zymomonas mobilis subsp. mobilis NRRL B-12526

Toxin (Protein)


Gene name pmenT Uniprot ID A0A806D022
Locus tag A254_RS09120 Protein ID WP_012954779.1
Coordinates 23737..24381 (+) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID A0A806D8U1
Locus tag A254_RS09125 Protein ID WP_012954778.1
Coordinates 24381..25460 (+) Length 360 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A254_RS09100 19662..20984 + 1323 WP_012954782.1 hypothetical protein -
A254_RS09105 21031..21831 + 801 WP_012954781.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
A254_RS09820 22089..22880 - 792 Protein_17 IS5 family transposase -
A254_RS09120 23737..24381 + 645 WP_012954779.1 DUF4433 domain-containing protein Toxin
A254_RS09125 24381..25460 + 1080 WP_012954778.1 macro domain-containing protein Antitoxin
A254_RS09130 26034..26495 - 462 WP_025420257.1 hypothetical protein -
A254_RS09140 26957..27274 + 318 WP_012954800.1 hypothetical protein -
A254_RS09145 27399..27650 + 252 WP_011078096.1 DUF2312 domain-containing protein -
A254_RS09150 27757..29526 + 1770 WP_023593790.1 helix-turn-helix domain-containing protein -
A254_RS09825 29721..29918 + 198 WP_012954798.1 type II toxin-antitoxin system HicA family toxin -
A254_RS09155 29928..30353 + 426 WP_012954797.1 type II toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..30952 30952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 25002.73 Da        Isoelectric Point: 7.4075

>T44860 WP_012954779.1 NZ_CP003711:23737-24381 [Zymomonas mobilis subsp. mobilis NRRL B-12526]
MIYKSFNPQKALIWRIVHYSNLPWILDNGLYCGNSKIKSPNWFNIGNPELIQKRADHSVPLPPSGMLNDYIPFYFTPFSP
MLRNISTGWGGIPQLPNEKIIILVSSLHHIADLGLPFLFTDSHAYSPCANYYSNLSDLNQIDWPILQHRDFKRDPDDPAK
FERYQAEALIYQHLPINGLYGIICYTELLKQRIEQEICARNLNLRVYARPEWYF

Download         Length: 645 bp

>T44860 NZ_CP003711:23737-24381 [Zymomonas mobilis subsp. mobilis NRRL B-12526]
ATGATCTATAAAAGTTTTAATCCACAAAAAGCATTGATATGGCGGATTGTCCATTACAGCAATTTGCCATGGATTTTGGA
TAATGGTCTCTACTGTGGCAATAGTAAGATAAAATCACCCAATTGGTTTAATATTGGCAATCCTGAATTAATCCAAAAAC
GCGCTGACCATTCAGTACCACTGCCTCCATCTGGGATGCTGAATGACTATATACCATTTTACTTCACACCATTTTCTCCG
ATGTTACGGAATATTTCGACAGGCTGGGGCGGTATACCCCAATTACCCAATGAGAAAATTATAATTTTGGTATCCAGTCT
TCACCATATTGCTGATCTGGGATTACCCTTTCTTTTTACAGATAGTCATGCCTACTCTCCGTGCGCTAATTATTACTCTA
ACCTATCTGATCTTAACCAGATCGATTGGCCAATATTGCAACATAGAGATTTTAAACGTGACCCAGATGATCCTGCCAAA
TTTGAGCGATATCAGGCTGAAGCACTTATTTACCAGCATTTGCCGATCAACGGACTATATGGCATTATATGTTATACAGA
ATTGTTGAAACAACGCATTGAGCAAGAGATTTGTGCTCGTAATCTCAATCTTCGGGTTTATGCCCGACCGGAATGGTATT
TCTGA

Antitoxin


Download         Length: 360 a.a.        Molecular weight: 40879.22 Da        Isoelectric Point: 9.1190

>AT44860 WP_012954778.1 NZ_CP003711:24381-25460 [Zymomonas mobilis subsp. mobilis NRRL B-12526]
MIIFTQGNLLEAKVEALVNTVNTVGVMGKGIALMFKERFHENFRLYSAACKAKEVQIGKMFVTPVYELGETRWIVNFPTK
QHWRNPSRIEWIIKGLQDLRRVLLEKNIKSIAIPPLGAGNGGLSWKDVRGQIELALSDLDIDIFVFEPTSQYQNVAKRTG
VEKLTPARALIAELVRRYWVMGIECSLLEIQKLAWFLQRAIEQYSPDNNPLNLDFQPHKYGPYTHQLNHLLNSLDGSYLH
SDKRISDSDPLDVILFVNKRKDDLQAYLKSEAKPYRQALESAAMLIDGFESPFGMELLATVDWLLTRENIEPNVPALRKG
LRSWRGGEDAALRKDRIFNDRSLGIALDRLTKTSTLAIA

Download         Length: 1080 bp

>AT44860 NZ_CP003711:24381-25460 [Zymomonas mobilis subsp. mobilis NRRL B-12526]
ATGATTATCTTCACGCAAGGCAACCTACTAGAAGCTAAAGTCGAGGCTCTTGTTAATACCGTTAACACCGTCGGTGTGAT
GGGTAAGGGTATTGCGCTCATGTTTAAAGAGCGCTTCCACGAGAACTTTCGCCTGTATTCTGCTGCGTGTAAGGCTAAGG
AAGTTCAAATCGGTAAGATGTTCGTTACTCCAGTCTATGAACTAGGGGAAACACGCTGGATTGTGAACTTTCCGACTAAA
CAGCATTGGCGTAATCCGTCACGAATAGAATGGATTATAAAAGGCTTACAGGATCTACGGCGTGTCCTGCTCGAAAAGAA
TATAAAATCTATTGCTATTCCTCCTTTGGGTGCTGGCAATGGCGGGCTTTCATGGAAAGATGTTCGTGGACAGATCGAGT
TGGCCTTAAGTGATCTCGATATTGATATTTTTGTGTTTGAGCCGACTAGCCAATACCAAAACGTGGCTAAGAGGACAGGC
GTAGAAAAACTAACGCCTGCGCGCGCCTTAATAGCTGAATTAGTCCGTCGATACTGGGTAATGGGTATAGAATGCAGTTT
GCTTGAAATTCAAAAGCTGGCTTGGTTTCTTCAGAGAGCTATTGAACAGTATTCTCCAGATAATAATCCACTGAATTTAG
ATTTTCAGCCACATAAATATGGTCCTTATACTCATCAGCTAAACCACTTGTTGAATAGTTTAGATGGCAGCTATCTTCAC
TCTGATAAACGTATCAGCGATAGCGACCCGCTGGATGTCATTTTATTTGTTAATAAGCGCAAAGACGATTTACAGGCTTA
TTTGAAAAGTGAGGCCAAGCCTTATAGGCAAGCGTTAGAATCTGCCGCCATGCTCATTGATGGTTTTGAGTCCCCCTTTG
GGATGGAACTGCTGGCTACAGTTGACTGGCTGCTAACTCGCGAAAATATAGAACCTAATGTGCCAGCTTTACGTAAGGGA
TTGCGTTCTTGGCGAGGTGGTGAAGATGCGGCCTTGCGTAAAGATCGAATTTTTAATGACCGATCTTTGGGGATTGCGCT
TGATCGCTTAACTAAAACCTCTACGCTTGCAATAGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806D022

Antitoxin

Source ID Structure
AlphaFold DB A0A806D8U1

References