Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 6917..7704 Replicon plasmid pZM1252601
Accession NZ_CP003710
Organism Zymomonas mobilis subsp. mobilis NRRL B-12526

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A806CGA0
Locus tag A254_RS08935 Protein ID WP_012954728.1
Coordinates 7210..7704 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A806DAA8
Locus tag A254_RS08930 Protein ID WP_012817668.1
Coordinates 6917..7213 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A254_RS08900 3056..3307 - 252 WP_012954734.1 DUF2312 domain-containing protein -
A254_RS08905 3432..3749 - 318 WP_012954732.1 hypothetical protein -
A254_RS08910 4211..4720 + 510 WP_023602514.1 hypothetical protein -
A254_RS08915 4735..5196 + 462 WP_012954730.1 hypothetical protein -
A254_RS08920 5765..6025 - 261 WP_012817666.1 ribbon-helix-helix protein, CopG family -
A254_RS08925 6055..6705 - 651 WP_012954729.1 AAA family ATPase -
A254_RS08930 6917..7213 + 297 WP_012817668.1 DUF1778 domain-containing protein Antitoxin
A254_RS08935 7210..7704 + 495 WP_012954728.1 GNAT family N-acetyltransferase Toxin
A254_RS08940 7785..9236 - 1452 WP_012954727.1 NAD-dependent succinate-semialdehyde dehydrogenase -
A254_RS08945 9239..10495 - 1257 WP_012954726.1 MFS transporter -
A254_RS08950 10499..12586 - 2088 WP_144081078.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33915 33915


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-144)

Antitoxin

Vibrio phage ICP1, Orf50

(8-97)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18093.13 Da        Isoelectric Point: 10.1331

>T44859 WP_012954728.1 NZ_CP003710:7210-7704 [Zymomonas mobilis subsp. mobilis NRRL B-12526]
VTITAPELLSPEHQVDLFQSGVESLDLWLKKRALKNQMTGASRTFVACKNRRVIAYYALASSAITIKSAHGRFRRNMPDP
IPVVVLGRLAIDQSLHNQGVGRAMVRDAALRIIQAADTIGIRGMLVHALSDEAKSFYEHIGFEPSPIDPMMLMVTLADLK
NSIK

Download         Length: 495 bp

>T44859 NZ_CP003710:7210-7704 [Zymomonas mobilis subsp. mobilis NRRL B-12526]
GTGACAATAACAGCCCCAGAATTATTATCCCCAGAACATCAAGTTGACTTATTTCAATCTGGTGTAGAGAGCCTTGATCT
ATGGCTGAAAAAGCGTGCTTTAAAAAACCAAATGACAGGAGCCTCTCGCACATTTGTAGCCTGTAAAAATCGACGGGTGA
TAGCTTATTATGCTCTAGCATCTAGCGCTATCACTATAAAATCAGCCCATGGACGATTTAGGCGTAATATGCCAGATCCT
ATTCCTGTTGTCGTTTTAGGGCGGCTTGCTATTGATCAATCTTTACATAACCAAGGCGTTGGACGAGCAATGGTAAGGGA
TGCAGCCTTAAGGATAATACAGGCAGCTGATACTATCGGCATTAGAGGTATGCTCGTTCATGCGCTATCTGATGAAGCCA
AATCTTTCTACGAACATATCGGTTTCGAACCGTCTCCAATCGACCCAATGATGTTGATGGTTACATTAGCCGATTTAAAA
AATAGTATAAAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11269.03 Da        Isoelectric Point: 9.8305

>AT44859 WP_012817668.1 NZ_CP003710:6917-7213 [Zymomonas mobilis subsp. mobilis NRRL B-12526]
MVATTTISSPNKREALNIRIKPEERDLIDRAAKIQRKSRTDFVLEAACRAAEEALFDQLIITVDPKAYTNFLTRLDMPPR
PNDRLQKTMQTVAPWDKL

Download         Length: 297 bp

>AT44859 NZ_CP003710:6917-7213 [Zymomonas mobilis subsp. mobilis NRRL B-12526]
ATGGTAGCCACAACAACAATATCCTCACCAAACAAACGAGAAGCGCTGAATATTAGAATTAAACCGGAAGAACGTGATTT
AATAGATCGAGCGGCAAAAATTCAGAGAAAAAGCCGTACTGATTTTGTATTAGAGGCAGCTTGTAGGGCTGCAGAAGAAG
CATTGTTCGATCAATTAATCATTACTGTAGATCCCAAGGCCTATACTAATTTCTTAACACGCCTTGATATGCCACCACGC
CCAAATGATCGGCTGCAAAAAACCATGCAAACGGTAGCTCCGTGGGATAAACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806CGA0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DAA8

References