Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 1289898..1290416 Replicon chromosome
Accession NZ_CP003560
Organism Flammeovirga sp. MY04

Toxin (Protein)


Gene name relE Uniprot ID A0A1B1FQJ4
Locus tag MY04_RS05160 Protein ID WP_066207310.1
Coordinates 1289898..1290167 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1B1FQK3
Locus tag MY04_RS05165 Protein ID WP_066207313.1
Coordinates 1290168..1290416 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY04_RS05150 1286129..1287427 - 1299 WP_066207304.1 dicarboxylate/amino acid:cation symporter -
MY04_RS05155 1287697..1289835 - 2139 WP_066207307.1 S9 family peptidase -
MY04_RS05160 1289898..1290167 - 270 WP_066207310.1 Txe/YoeB family addiction module toxin Toxin
MY04_RS05165 1290168..1290416 - 249 WP_066207313.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MY04_RS05170 1290468..1290980 + 513 WP_066207316.1 DUF255 domain-containing protein -
MY04_RS05175 1291596..1293050 - 1455 WP_066207318.1 aminoacyl-histidine dipeptidase -
MY04_RS05180 1293099..1293815 - 717 WP_066207324.1 leucyl/phenylalanyl-tRNA--protein transferase -
MY04_RS05185 1294051..1295310 + 1260 WP_066207325.1 T9SS type A sorting domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10848.55 Da        Isoelectric Point: 10.5642

>T44858 WP_066207310.1 NZ_CP003560:c1290167-1289898 [Flammeovirga sp. MY04]
MNILFSKTAWQQYLFWQTEDKKITLRIHELIKNIQRDPFKGIGKPEPLRQNLTGFWSRRINSEHRLIYRIVGKKNEGQRT
EIISCQYHY

Download         Length: 270 bp

>T44858 NZ_CP003560:c1290167-1289898 [Flammeovirga sp. MY04]
ATGAATATACTATTCTCAAAAACTGCTTGGCAACAATACTTATTCTGGCAAACTGAAGACAAAAAAATAACTTTAAGGAT
ACATGAGTTAATAAAAAACATTCAAAGAGATCCATTTAAAGGTATTGGTAAACCAGAACCTCTACGTCAAAATCTAACCG
GATTTTGGTCAAGAAGAATTAATTCAGAACACCGTTTGATTTATCGAATTGTAGGAAAGAAAAATGAAGGACAGAGAACT
GAAATAATATCTTGTCAATATCATTATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9476.70 Da        Isoelectric Point: 4.3030

>AT44858 WP_066207313.1 NZ_CP003560:c1290416-1290168 [Flammeovirga sp. MY04]
MNTTTLSDLRANLKSYFDELEDNKDILIVPRSGNKEAIVLMTLSEYNSMKETEYLLSSKNNRELLEKSIKELDGEDTIKF
DL

Download         Length: 249 bp

>AT44858 NZ_CP003560:c1290416-1290168 [Flammeovirga sp. MY04]
ATGAATACAACGACTTTAAGTGATTTAAGAGCGAATCTTAAATCATATTTCGATGAGTTAGAAGATAACAAAGATATTTT
AATTGTTCCAAGAAGTGGTAACAAAGAAGCTATCGTATTGATGACTTTATCAGAATATAACAGTATGAAGGAAACTGAAT
ATTTATTATCTTCAAAAAACAATCGAGAGCTACTCGAAAAATCAATAAAAGAACTTGACGGTGAAGATACTATCAAATTT
GATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1FQJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1FQK3

References