Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4160124..4160793 Replicon chromosome
Accession NZ_CP003424
Organism Serratia sp. SCBI

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B4GZI3
Locus tag SERRSCBI_RS19465 Protein ID WP_042785308.1
Coordinates 4160124..4160546 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8B4GS04
Locus tag SERRSCBI_RS19470 Protein ID WP_019455657.1
Coordinates 4160527..4160793 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERRSCBI_RS19445 4156051..4157784 - 1734 WP_033639478.1 single-stranded-DNA-specific exonuclease RecJ -
SERRSCBI_RS19450 4157791..4158507 - 717 WP_042785306.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SERRSCBI_RS19455 4158534..4159433 - 900 WP_033644935.1 site-specific tyrosine recombinase XerD -
SERRSCBI_RS19460 4159540..4160058 + 519 WP_042785307.1 flavodoxin FldB -
SERRSCBI_RS19465 4160124..4160546 - 423 WP_042785308.1 protein YgfX Toxin
SERRSCBI_RS19470 4160527..4160793 - 267 WP_019455657.1 FAD assembly factor SdhE Antitoxin
SERRSCBI_RS19480 4161113..4162105 + 993 WP_042785310.1 tRNA-modifying protein YgfZ -
SERRSCBI_RS19485 4162144..4162641 - 498 WP_042785311.1 DUF2165 domain-containing protein -
SERRSCBI_RS19490 4162792..4163466 - 675 WP_033644772.1 hemolysin III family protein -
SERRSCBI_RS19495 4163650..4164258 + 609 WP_033644771.1 HD domain-containing protein -
SERRSCBI_RS19500 4164299..4165225 - 927 WP_042785312.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16527.59 Da        Isoelectric Point: 10.8114

>T44855 WP_042785308.1 NZ_CP003424:c4160546-4160124 [Serratia sp. SCBI]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEQD

Download         Length: 423 bp

>T44855 NZ_CP003424:c4160546-4160124 [Serratia sp. SCBI]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTCTCTCTGTTGACCCACGGCGTCCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCTGCGGTGCAGGGTGAACTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGA
GAATGGCGGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCCTGCTGCTGACGTTACAGCCTATGGAGGGCAAAAAGCG
CCGTCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAACAAGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10417.91 Da        Isoelectric Point: 4.7921

>AT44855 WP_019455657.1 NZ_CP003424:c4160793-4160527 [Serratia sp. SCBI]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT44855 NZ_CP003424:c4160793-4160527 [Serratia sp. SCBI]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCACTGTTCATCCGTCTGCTCGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAAAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GS04

References