Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1579562..1580109 Replicon chromosome
Accession NZ_CP003424
Organism Serratia sp. SCBI

Toxin (Protein)


Gene name ccdB Uniprot ID A0A380ADA6
Locus tag SERRSCBI_RS07385 Protein ID WP_025302144.1
Coordinates 1579801..1580109 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3SUU9
Locus tag SERRSCBI_RS07380 Protein ID WP_033633717.1
Coordinates 1579562..1579798 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERRSCBI_RS07365 1576048..1577583 + 1536 WP_042784031.1 glutathione ABC transporter substrate-binding protein GsiB -
SERRSCBI_RS07370 1577636..1578556 + 921 WP_042784032.1 glutathione ABC transporter permease GsiC -
SERRSCBI_RS07375 1578566..1579474 + 909 WP_169539470.1 glutathione ABC transporter permease GsiD -
SERRSCBI_RS07380 1579562..1579798 + 237 WP_033633717.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SERRSCBI_RS07385 1579801..1580109 + 309 WP_025302144.1 CcdB family protein Toxin
SERRSCBI_RS07390 1580146..1580988 - 843 WP_015377214.1 S-formylglutathione hydrolase -
SERRSCBI_RS07395 1581003..1582128 - 1126 Protein_1459 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
SERRSCBI_RS07400 1582159..1583079 - 921 WP_042784035.1 LysR family transcriptional regulator -
SERRSCBI_RS07405 1583185..1584342 + 1158 WP_042784036.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11504.32 Da        Isoelectric Point: 5.0196

>T44845 WP_025302144.1 NZ_CP003424:1579801-1580109 [Serratia sp. SCBI]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T44845 NZ_CP003424:1579801-1580109 [Serratia sp. SCBI]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCCATCGATTTTCTGATTGATGGTTTTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8994.07 Da        Isoelectric Point: 5.0807

>AT44845 WP_033633717.1 NZ_CP003424:1579562-1579798 [Serratia sp. SCBI]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT44845 NZ_CP003424:1579562-1579798 [Serratia sp. SCBI]
ATGGCAAATAACAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGCTTGTTGTCTGATGAATATCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380ADA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SUU9

References