Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1096499..1097121 Replicon chromosome
Accession NZ_CP003424
Organism Serratia sp. SCBI

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag SERRSCBI_RS05085 Protein ID WP_004940313.1
Coordinates 1096499..1096702 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag SERRSCBI_RS05090 Protein ID WP_004940312.1
Coordinates 1096753..1097121 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERRSCBI_RS05060 1092308..1092772 + 465 WP_042783799.1 type II secretion system protein M -
SERRSCBI_RS05065 1092788..1093603 + 816 WP_049866650.1 A24 family peptidase -
SERRSCBI_RS05070 1093600..1093962 - 363 WP_033642100.1 type II secretion system pilot lipoprotein GspS -
SERRSCBI_RS05075 1094220..1095647 + 1428 WP_042783800.1 N-acetylglucosamine-binding protein GbpA -
SERRSCBI_RS05080 1095700..1096217 + 518 Protein_997 cytochrome b/b6 domain-containing protein -
SERRSCBI_RS05085 1096499..1096702 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
SERRSCBI_RS05090 1096753..1097121 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
SERRSCBI_RS05095 1097281..1097635 - 355 Protein_1000 hypothetical protein -
SERRSCBI_RS05105 1098043..1098756 + 714 WP_042783802.1 ABC transporter ATP-binding protein -
SERRSCBI_RS05110 1098753..1099610 + 858 WP_042783803.1 metal ABC transporter permease -
SERRSCBI_RS05115 1099636..1100514 + 879 WP_042783804.1 zinc ABC transporter substrate-binding protein -
SERRSCBI_RS05120 1100622..1100762 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
SERRSCBI_RS05125 1100775..1101029 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T44844 WP_004940313.1 NZ_CP003424:c1096702-1096499 [Serratia sp. SCBI]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T44844 NZ_CP003424:c1096702-1096499 [Serratia sp. SCBI]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAAAAAAATAA
GTACGAGCTTTCCGATGATGAACTAGAGCTGTTTTACTCAGCCGCCGATCATCGTTTGGCGGAGCTGACCATGAACAAGC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT44844 WP_004940312.1 NZ_CP003424:c1097121-1096753 [Serratia sp. SCBI]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT44844 NZ_CP003424:c1097121-1096753 [Serratia sp. SCBI]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAACTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
CACCCTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTTCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCCGATTTGTCGGAGTTAGTCGAGGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References