Detailed information of TA system TA044843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 211662..212134
• Replicon: chromosome
• Accession: NZ_CP003424
• Organism: Serratia sp. SCBI

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8B4GM79
• Locus tag: SERRSCBI_RS00940
• Protein ID: WP_033645001.1
• Coordinates: 211859..212134 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SERRSCBI_RS00935
• Protein ID: WP_033645226.1
• Coordinates: 211662..211859 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SERRSCBI_RS00905	206849..208117	+	1269	WP_038874127.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-
SERRSCBI_RS00910	208114..209313	+	1200	WP_033652425.1	anaerobic glycerol-3-phosphate dehydrogenase subunit C	-
SERRSCBI_RS00915	209348..209911	-	564	WP_025304887.1	DcrB family lipoprotein	-
SERRSCBI_RS00920	209992..210426	-	435	WP_042783453.1	GNAT family N-acetyltransferase	-
SERRSCBI_RS00925	210468..211127	-	660	WP_042783454.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
SERRSCBI_RS00930	211352..211597	+	246	WP_025304890.1	sulfurtransferase TusA	-
SERRSCBI_RS00935	211662..211859	+	198	WP_033645226.1	hypothetical protein	Antitoxin
SERRSCBI_RS00940	211859..212134	+	276	WP_033645001.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
SERRSCBI_RS00945	212194..214512	-	2319	WP_042783455.1	zinc/cadmium/mercury/lead-transporting ATPase	-
SERRSCBI_RS00950	215193..216656	+	1464	WP_033652421.1	serralysin family metalloprotease	-
SERRSCBI_RS00955	216711..217088	+	378	WP_025304893.1	AprI/Inh family metalloprotease inhibitor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10682.57 Da
• Isoelectric Point: 11.2806

>T44843 WP_033645001.1 NZ_CP003424:211859-212134 [Serratia sp. SCBI]
MLNIEWTRAARQDLAEIVGFIANDNPLAARKMKVLIMEAVTPAARHPRIFRRGRVDGTHEIPLHPHYLLIYQVLETHIRV
LRVLHTRRQYP

Nucleotide

• Length: 276 bp

>T44843 NZ_CP003424:211859-212134 [Serratia sp. SCBI]
ATGCTCAACATCGAATGGACTCGAGCCGCACGTCAGGATCTGGCGGAGATTGTGGGATTCATCGCCAACGATAACCCTCT
GGCAGCCAGAAAAATGAAGGTTCTCATCATGGAGGCCGTCACTCCCGCCGCCAGGCATCCTCGAATTTTCCGGCGTGGTA
GAGTGGACGGCACGCATGAAATCCCCTTGCATCCCCATTATCTCCTGATTTACCAGGTGCTGGAAACTCACATCCGGGTG
TTGCGGGTATTACATACGCGCCGACAATATCCTTAG

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7395.40 Da
• Isoelectric Point: 4.1359

>AT44843 WP_033645226.1 NZ_CP003424:211662-211859 [Serratia sp. SCBI]
MSILLLPTVAKMENEEHTQGYERWFLERVQEAMDEPWPGIPHDDVMAEMDAVIAAAEARINAKQA

Nucleotide

• Length: 198 bp

>AT44843 NZ_CP003424:211662-211859 [Serratia sp. SCBI]
ATGAGTATTTTACTACTGCCTACGGTTGCCAAGATGGAAAATGAGGAACACACACAGGGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCGTGGCCCGGTATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAACGCGAAGCAGGCATAA

Structures

Toxin

• AlphaFold DB: A0A8B4GM79