Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 44016..44617 Replicon chromosome
Accession NZ_CP003424
Organism Serratia sp. SCBI

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag SERRSCBI_RS00210 Protein ID WP_025304766.1
Coordinates 44016..44396 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag SERRSCBI_RS00215 Protein ID WP_025304767.1
Coordinates 44396..44617 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERRSCBI_RS00185 39263..40543 + 1281 WP_033652318.1 DUF3748 domain-containing protein -
SERRSCBI_RS00190 40574..40921 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
SERRSCBI_RS00195 41231..41644 + 414 WP_004933919.1 heat shock chaperone IbpA -
SERRSCBI_RS00200 41751..42179 + 429 WP_004933922.1 heat shock chaperone IbpB -
SERRSCBI_RS00205 42347..44005 + 1659 WP_042783386.1 putative transporter -
SERRSCBI_RS00210 44016..44396 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
SERRSCBI_RS00215 44396..44617 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
SERRSCBI_RS00220 44692..45942 - 1251 WP_004933935.1 valine--pyruvate transaminase -
SERRSCBI_RS00225 46958..47737 + 780 WP_033645137.1 2OG-Fe dioxygenase family protein -
SERRSCBI_RS24480 47817..48485 + 669 WP_084587938.1 PLP-dependent aspartate aminotransferase family protein -
SERRSCBI_RS24485 48470..48955 + 486 WP_128868651.1 PLP-dependent transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T44841 WP_025304766.1 NZ_CP003424:c44396-44016 [Serratia sp. SCBI]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T44841 NZ_CP003424:c44396-44016 [Serratia sp. SCBI]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAGGGACGTTCT
GGTCGAGTATCACATCAATCCGGCCATCAGCGCCATCACCTGGATGGAAGTGATGGTAGGTGCTAAAAAACAGGGTCCGG
CACTGGAGCTGAAAACACGTCAGTTTTTAGGGCAATTTCTGCTGCTGCCTATTACCGATGAAGTCGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAACTGCCAGACGCCATTATCTGGGCCACCGCGCAGGTGGGATTCCGGATGCTCAT
CTCCCGCAACCCCAAAGATTTCGGCACTGACAATGGCGTGTTGATGCCTTATCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT44841 WP_025304767.1 NZ_CP003424:c44617-44396 [Serratia sp. SCBI]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT44841 NZ_CP003424:c44617-44396 [Serratia sp. SCBI]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGATAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAGATCATTCGTCAAGCAGTCTCTCGCTATCTGACGGAGAACCACGTGGAAGATCCCAGCAACGCTTTCGGGCTCT
GGTCCGGGGCGATGGGAGATGGCGTGGAGTACGAAAATCGTCAGCGTGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References