Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1489470..1489915 Replicon chromosome
Accession NZ_CP003408
Organism Thermotoga sp. 2812B

Toxin (Protein)


Gene name hicA Uniprot ID D2C4B8
Locus tag T2812B_RS07710 Protein ID WP_008195297.1
Coordinates 1489685..1489915 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID Q9X145
Locus tag T2812B_RS07705 Protein ID WP_004083352.1
Coordinates 1489470..1489688 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
T2812B_RS07690 1485431..1486759 - 1329 WP_008195284.1 radical SAM protein -
T2812B_RS07700 1487766..1489373 + 1608 WP_008195290.1 tetratricopeptide repeat protein -
T2812B_RS07705 1489470..1489688 + 219 WP_004083352.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
T2812B_RS07710 1489685..1489915 + 231 WP_008195297.1 type II toxin-antitoxin system HicA family toxin Toxin
T2812B_RS07715 1489938..1490183 + 246 Protein_1486 hypothetical protein -
T2812B_RS07720 1490320..1492062 - 1743 WP_008195299.1 ABC transporter ATP-binding protein/permease -
T2812B_RS09600 1492125..1492894 - 770 Protein_1488 ABC transporter permease -
T2812B_RS07735 1492898..1493332 - 435 WP_004079914.1 ABC transporter permease -
T2812B_RS07745 1493550..1494356 - 807 WP_004079915.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-57)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8881.54 Da        Isoelectric Point: 11.0394

>T44840 WP_008195297.1 NZ_CP003408:1489685-1489915 [Thermotoga sp. 2812B]
MSYLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGRYTTIPFHARALPKSLIRKIIREAGISVEEFKKVLENL

Download         Length: 231 bp

>T44840 NZ_CP003408:1489685-1489915 [Thermotoga sp. 2812B]
TTGAGTTATCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGCAGATATACGACCATCCCATTTCATGCAAGAGCCTTGCCCAAATCAC
TTATAAGAAAAATCATCCGTGAAGCGGGTATATCAGTGGAGGAATTCAAGAAAGTACTTGAAAATCTGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8183.29 Da        Isoelectric Point: 4.0887

>AT44840 WP_004083352.1 NZ_CP003408:1489470-1489688 [Thermotoga sp. 2812B]
VRKIFTAIIEYDPETKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINHQEFVALEMIEVET

Download         Length: 219 bp

>AT44840 NZ_CP003408:1489470-1489688 [Thermotoga sp. 2812B]
GTGCGCAAAATTTTCACAGCTATCATTGAATACGATCCTGAAACAAAGCAATATGTTGGAATGGTTCCGGACGTTCCGGG
TGTGCATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCACCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B5L026

Antitoxin

Source ID Structure
AlphaFold DB A0A0A6N0B1

References