44834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3825404..3826089 Replicon chromosome
Accession NZ_CP002885
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag CFBR_RS18015 Protein ID WP_003417998.1
Coordinates 3825679..3826089 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CFBR_RS18010 Protein ID WP_180895138.1
Coordinates 3825404..3825682 (+) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBR_RS17990 3821393..3822994 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
CFBR_RS17995 3823011..3823715 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
CFBR_RS18000 3823833..3824399 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
CFBR_RS18005 3824461..3825348 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
CFBR_RS18010 3825404..3825682 + 279 WP_180895138.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CFBR_RS18015 3825679..3826089 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
CFBR_RS18020 3826122..3827858 - 1737 WP_003418002.1 cholesterol oxidase -
CFBR_RS18025 3827914..3829041 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
CFBR_RS18030 3829061..3830650 - 1590 WP_003901630.1 IMP dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-118)

Antitoxin

(3-58)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T44834 WP_003417998.1 NZ_CP002885:3825679-3826089 [Mycobacterium tuberculosis CCDC5180]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T44834 NZ_CP002885:3825679-3826089 [Mycobacterium tuberculosis CCDC5180]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10227.70 Da        Isoelectric Point: 8.0222

>AT44834 WP_180895138.1 NZ_CP002885:3825404-3825682 [Mycobacterium tuberculosis CCDC5180]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGCKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT44834 NZ_CP002885:3825404-3825682 [Mycobacterium tuberculosis CCDC5180]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCTGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TIR9


Antitoxin

Source ID Structure

References