Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3700416..3701090 Replicon chromosome
Accession NZ_CP002885
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag CFBR_RS17535 Protein ID WP_003417282.1
Coordinates 3700416..3700844 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag CFBR_RS17540 Protein ID WP_003417286.1
Coordinates 3700848..3701090 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBR_RS17510 3696238..3696639 - 402 WP_003417264.1 cytidine deaminase -
CFBR_RS17515 3696780..3697214 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
CFBR_RS17520 3697211..3697645 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
CFBR_RS17525 3697774..3699546 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
CFBR_RS17530 3699546..3700337 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
CFBR_RS17535 3700416..3700844 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
CFBR_RS17540 3700848..3701090 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
CFBR_RS17545 3701212..3701826 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
CFBR_RS17550 3701823..3702488 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
CFBR_RS17555 3702489..3703022 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
CFBR_RS17560 3703019..3703393 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
CFBR_RS17565 3703490..3704554 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T44831 WP_003417282.1 NZ_CP002885:c3700844-3700416 [Mycobacterium tuberculosis CCDC5180]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T44831 NZ_CP002885:c3700844-3700416 [Mycobacterium tuberculosis CCDC5180]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT44831 WP_003417286.1 NZ_CP002885:c3701090-3700848 [Mycobacterium tuberculosis CCDC5180]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT44831 NZ_CP002885:c3701090-3700848 [Mycobacterium tuberculosis CCDC5180]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References