Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2922848..2923562 Replicon chromosome
Accession NZ_CP002885
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag CFBR_RS13725 Protein ID WP_003413460.1
Coordinates 2923122..2923562 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag CFBR_RS13720 Protein ID WP_003413456.1
Coordinates 2922848..2923135 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBR_RS13685 2918270..2918515 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CFBR_RS13690 2918512..2918916 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
CFBR_RS13695 2919133..2919753 + 621 WP_003413441.1 DUF4178 domain-containing protein -
CFBR_RS13700 2919764..2920258 + 495 WP_003413444.1 DUF2617 family protein -
CFBR_RS13705 2920255..2920686 + 432 WP_003899390.1 DUF4247 domain-containing protein -
CFBR_RS13710 2920711..2921169 + 459 WP_003413451.1 DUF350 domain-containing protein -
CFBR_RS13715 2921166..2922737 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
CFBR_RS13720 2922848..2923135 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
CFBR_RS13725 2923122..2923562 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
CFBR_RS13730 2923583..2924338 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
CFBR_RS13735 2924471..2925067 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
CFBR_RS13740 2925075..2925920 - 846 WP_003413466.1 acyl-CoA thioesterase II -
CFBR_RS13745 2925949..2926848 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
CFBR_RS13750 2926976..2927650 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T44821 WP_003413460.1 NZ_CP002885:2923122-2923562 [Mycobacterium tuberculosis CCDC5180]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T44821 NZ_CP002885:2923122-2923562 [Mycobacterium tuberculosis CCDC5180]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT44821 WP_003413456.1 NZ_CP002885:2922848-2923135 [Mycobacterium tuberculosis CCDC5180]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT44821 NZ_CP002885:2922848-2923135 [Mycobacterium tuberculosis CCDC5180]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References