Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2860933..2861642 Replicon chromosome
Accession NZ_CP002885
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag CFBR_RS13440 Protein ID WP_003413164.1
Coordinates 2860933..2861346 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag CFBR_RS13445 Protein ID WP_003413167.1
Coordinates 2861385..2861642 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBR_RS13415 2855987..2857192 - 1206 WP_003413027.1 chorismate synthase -
CFBR_RS13420 2857300..2857614 + 315 WP_009937839.1 hypothetical protein -
CFBR_RS13425 2857910..2859121 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
CFBR_RS13430 2859248..2859907 + 660 WP_003902296.1 hypothetical protein -
CFBR_RS13435 2859904..2860566 + 663 WP_003905878.1 hypothetical protein -
CFBR_RS22295 2860563..2860840 + 278 Protein_2625 type II toxin-antitoxin system VapB family antitoxin -
CFBR_RS13440 2860933..2861346 + 414 WP_003413164.1 PIN domain nuclease Toxin
CFBR_RS13445 2861385..2861642 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
CFBR_RS13450 2861639..2862016 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
CFBR_RS13455 2862032..2862406 - 375 WP_003413177.1 hypothetical protein -
CFBR_RS13460 2862506..2862901 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
CFBR_RS13465 2862898..2863143 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
CFBR_RS13470 2863554..2863973 - 420 WP_003413190.1 A24 family peptidase -
CFBR_RS13475 2863985..2864794 - 810 WP_003413193.1 shikimate dehydrogenase -
CFBR_RS13480 2864791..2866044 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
CFBR_RS13485 2866037..2866549 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T44818 WP_003413164.1 NZ_CP002885:2860933-2861346 [Mycobacterium tuberculosis CCDC5180]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T44818 NZ_CP002885:2860933-2861346 [Mycobacterium tuberculosis CCDC5180]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT44818 WP_003413167.1 NZ_CP002885:2861385-2861642 [Mycobacterium tuberculosis CCDC5180]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT44818 NZ_CP002885:2861385-2861642 [Mycobacterium tuberculosis CCDC5180]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References