Detailed information of TA system TA044817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2847047..2847687
• Replicon: chromosome
• Accession: NZ_CP002885
• Organism: Mycobacterium tuberculosis CCDC5180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: CFBR_RS13360
• Protein ID: WP_003412970.1
• Coordinates: 2847047..2847466 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: CFBR_RS13365
• Protein ID: WP_003412975.1
• Coordinates: 2847463..2847687 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFBR_RS13335	2842637..2843359	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
CFBR_RS13340	2843876..2844098	+	223	Protein_2604	type II toxin-antitoxin system VapB family antitoxin	-
CFBR_RS13345	2844095..2844496	+	402	WP_003412963.1	PIN domain-containing protein	-
CFBR_RS13350	2844531..2845451	-	921	WP_003412965.1	restriction endonuclease	-
CFBR_RS22645	2845792..2846037	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
CFBR_RS13355	2846096..2847046	+	951	WP_003911916.1	Lsr2 family protein	-
CFBR_RS13360	2847047..2847466	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
CFBR_RS13365	2847463..2847687	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
CFBR_RS13370	2847718..2850561	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
CFBR_RS13375	2850633..2851034	-	402	WP_003412981.1	hypothetical protein	-
CFBR_RS13380	2851034..2851504	-	471	WP_003899364.1	transcription antitermination factor NusB	-
CFBR_RS13385	2851507..2852070	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T44817 WP_003412970.1 NZ_CP002885:c2847466-2847047 [Mycobacterium tuberculosis CCDC5180]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T44817 NZ_CP002885:c2847466-2847047 [Mycobacterium tuberculosis CCDC5180]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT44817 WP_003412975.1 NZ_CP002885:c2847687-2847463 [Mycobacterium tuberculosis CCDC5180]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT44817 NZ_CP002885:c2847687-2847463 [Mycobacterium tuberculosis CCDC5180]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09