44811

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2248612..2249238 Replicon chromosome
Accession NZ_CP002885
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag CFBR_RS10535 Protein ID WP_003410075.1
Coordinates 2248840..2249238 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag CFBR_RS10530 Protein ID WP_003911750.1
Coordinates 2248612..2248839 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBR_RS10520 2246651..2246995 - 345 WP_003410065.1 ferredoxin family protein -
CFBR_RS10525 2247184..2248353 - 1170 WP_003899126.1 ATP-binding protein -
CFBR_RS10530 2248612..2248839 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CFBR_RS10535 2248840..2249238 + 399 WP_003410075.1 PIN domain nuclease Toxin
CFBR_RS10540 2249421..2249852 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
CFBR_RS10545 2249953..2250387 + 435 WP_003914358.1 DUF1398 domain-containing protein -
CFBR_RS21405 2250824..2251003 - 180 Protein_2070 hypothetical protein -
CFBR_RS10550 2251064..2251711 + 648 WP_071854215.1 transposase -
CFBR_RS10555 2251665..2252255 + 591 WP_003899131.1 IS110 family transposase -
CFBR_RS10560 2252383..2253639 - 1257 WP_003902247.1 HNH endonuclease -
CFBR_RS10565 2253993..2254193 + 201 Protein_2074 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T44811 WP_003410075.1 NZ_CP002885:2248840-2249238 [Mycobacterium tuberculosis CCDC5180]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T44811 NZ_CP002885:2248840-2249238 [Mycobacterium tuberculosis CCDC5180]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT44811 WP_003911750.1 NZ_CP002885:2248612-2248839 [Mycobacterium tuberculosis CCDC5180]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT44811 NZ_CP002885:2248612-2248839 [Mycobacterium tuberculosis CCDC5180]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References