Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1939476..1940089 Replicon chromosome
Accession NZ_CP002885
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag CFBR_RS09010 Protein ID WP_003408465.1
Coordinates 1939476..1939865 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag CFBR_RS09015 Protein ID WP_003408469.1
Coordinates 1939862..1940089 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBR_RS08980 1935103..1936017 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
CFBR_RS08985 1936020..1936850 + 831 WP_003408448.1 cyclase family protein -
CFBR_RS08990 1936850..1937200 + 351 WP_003898986.1 cupin domain-containing protein -
CFBR_RS08995 1937253..1938071 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
CFBR_RS09000 1938085..1938864 + 780 WP_003408460.1 IclR family transcriptional regulator -
CFBR_RS09010 1939476..1939865 - 390 WP_003408465.1 PIN domain-containing protein Toxin
CFBR_RS09015 1939862..1940089 - 228 WP_003408469.1 antitoxin Antitoxin
CFBR_RS09020 1940307..1941791 + 1485 WP_003408473.1 carboxylase -
CFBR_RS09025 1941788..1943035 + 1248 WP_003408476.1 serine hydrolase -
CFBR_RS09030 1943078..1943497 - 420 WP_003408483.1 hypothetical protein -
CFBR_RS09035 1943487..1944197 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T44803 WP_003408465.1 NZ_CP002885:c1939865-1939476 [Mycobacterium tuberculosis CCDC5180]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T44803 NZ_CP002885:c1939865-1939476 [Mycobacterium tuberculosis CCDC5180]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT44803 WP_003408469.1 NZ_CP002885:c1940089-1939862 [Mycobacterium tuberculosis CCDC5180]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT44803 NZ_CP002885:c1940089-1939862 [Mycobacterium tuberculosis CCDC5180]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References