Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1766430..1767043 Replicon chromosome
Accession NZ_CP002885
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag CFBR_RS08280 Protein ID WP_003407786.1
Coordinates 1766639..1767043 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag CFBR_RS08275 Protein ID WP_009935474.1
Coordinates 1766430..1766633 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBR_RS08245 1761835..1762215 + 381 WP_003407768.1 fumarate reductase subunit C -
CFBR_RS08250 1762212..1762589 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
CFBR_RS08255 1762657..1763265 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
CFBR_RS08260 1763449..1764597 + 1149 Protein_1613 MMPL family transporter -
CFBR_RS08265 1764607..1765053 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
CFBR_RS08270 1765088..1766377 + 1290 WP_003407781.1 threonine ammonia-lyase -
CFBR_RS08275 1766430..1766633 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CFBR_RS08280 1766639..1767043 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
CFBR_RS08285 1767060..1768802 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
CFBR_RS08290 1768795..1771092 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T44802 WP_003407786.1 NZ_CP002885:1766639-1767043 [Mycobacterium tuberculosis CCDC5180]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T44802 NZ_CP002885:1766639-1767043 [Mycobacterium tuberculosis CCDC5180]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT44802 WP_009935474.1 NZ_CP002885:1766430-1766633 [Mycobacterium tuberculosis CCDC5180]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT44802 NZ_CP002885:1766430-1766633 [Mycobacterium tuberculosis CCDC5180]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References