Detailed information of TA system TA044796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1236431..1236999
• Replicon: chromosome
• Accession: NZ_CP002885
• Organism: Mycobacterium tuberculosis CCDC5180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TH08
• Locus tag: CFBR_RS05895
• Protein ID: WP_003405865.1
• Coordinates: 1236625..1236999 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TH07
• Locus tag: CFBR_RS05890
• Protein ID: WP_003405863.1
• Coordinates: 1236431..1236628 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFBR_RS05870	1232472..1233110	-	639	WP_003898730.1	lipid droplet-associated protein	-
CFBR_RS05875	1233200..1234207	+	1008	WP_003405853.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
CFBR_RS05880	1234224..1235207	-	984	WP_003898731.1	hypothetical protein	-
CFBR_RS05885	1235270..1236343	+	1074	WP_003898732.1	redox-regulated ATPase YchF	-
CFBR_RS05890	1236431..1236628	+	198	WP_003405863.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
CFBR_RS05895	1236625..1236999	+	375	WP_003405865.1	type II toxin-antitoxin system VapC family toxin	Toxin
CFBR_RS05900	1237202..1237900	+	699	WP_003898733.1	hypothetical protein	-
CFBR_RS05905	1238018..1238203	+	186	WP_003901093.1	hypothetical protein	-
CFBR_RS05910	1238130..1238405	-	276	WP_003405867.1	hypothetical protein	-
CFBR_RS05915	1238648..1238971	+	324	WP_003405871.1	antibiotic biosynthesis monooxygenase	-
CFBR_RS05920	1238986..1239696	-	711	WP_003911399.1	hypothetical protein	-
CFBR_RS22535	1239718..1239927	+	210	WP_003911400.1	hypothetical protein	-
CFBR_RS05930	1239879..1240586	-	708	Protein_1159	adenylate/guanylate cyclase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13444.56 Da
• Isoelectric Point: 5.1881

>T44796 WP_003405865.1 NZ_CP002885:1236625-1236999 [Mycobacterium tuberculosis CCDC5180]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Nucleotide

• Length: 375 bp

>T44796 NZ_CP002885:1236625-1236999 [Mycobacterium tuberculosis CCDC5180]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 6973.03 Da
• Isoelectric Point: 11.7327

>AT44796 WP_003405863.1 NZ_CP002885:1236431-1236628 [Mycobacterium tuberculosis CCDC5180]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Nucleotide

• Length: 198 bp

>AT44796 NZ_CP002885:1236431-1236628 [Mycobacterium tuberculosis CCDC5180]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0TH08

Antitoxin

• AlphaFold DB: G0TH07