Detailed information of TA system TA044793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1013215..1013834
• Replicon: chromosome
• Accession: NZ_CP002885
• Organism: Mycobacterium tuberculosis CCDC5180

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: CFBR_RS04780
• Protein ID: WP_003404726.1
• Coordinates: 1013400..1013834 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: P9WJ06
• Locus tag: CFBR_RS04775
• Protein ID: WP_003898641.1
• Coordinates: 1013215..1013394 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFBR_RS04765	1008688..1010268	+	1581	WP_003910977.1	serine hydrolase	-
CFBR_RS04770	1010265..1012658	+	2394	WP_003898639.1	cation-translocating P-type ATPase	-
CFBR_RS22510	1012931..1013089	+	159	WP_003404720.1	hypothetical protein	-
CFBR_RS04775	1013215..1013394	+	180	WP_003898641.1	antitoxin	Antitoxin
CFBR_RS04780	1013400..1013834	+	435	WP_003404726.1	SRPBCC family protein	Toxin
CFBR_RS04785	1013932..1014705	+	774	WP_003404735.1	VOC family protein	-
CFBR_RS04790	1014770..1015219	+	450	WP_003404738.1	hypothetical protein	-
CFBR_RS04795	1015354..1015584	-	231	WP_003898642.1	hypothetical protein	-
CFBR_RS04800	1015751..1017259	-	1509	WP_003404742.1	carotenoid oxygenase family protein	-
CFBR_RS04805	1017261..1018499	-	1239	WP_003404744.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-50)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15754.47 Da
• Isoelectric Point: 9.7977

>T44793 WP_003404726.1 NZ_CP002885:1013400-1013834 [Mycobacterium tuberculosis CCDC5180]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Nucleotide

• Length: 435 bp

>T44793 NZ_CP002885:1013400-1013834 [Mycobacterium tuberculosis CCDC5180]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6403.07 Da
• Isoelectric Point: 4.5393

>AT44793 WP_003898641.1 NZ_CP002885:1013215-1013394 [Mycobacterium tuberculosis CCDC5180]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Nucleotide

• Length: 180 bp

>AT44793 NZ_CP002885:1013215-1013394 [Mycobacterium tuberculosis CCDC5180]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Structures

Antitoxin

• AlphaFold DB: A0A045KDK5