Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2919664..2920378 Replicon chromosome
Accession NZ_CP002883
Organism Mycobacterium tuberculosis BT1

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag HKBT1_RS13710 Protein ID WP_003413460.1
Coordinates 2919938..2920378 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag HKBT1_RS13705 Protein ID WP_003413456.1
Coordinates 2919664..2919951 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT1_RS13670 2915086..2915331 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HKBT1_RS13675 2915328..2915732 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
HKBT1_RS13680 2915949..2916569 + 621 WP_003413441.1 DUF4178 domain-containing protein -
HKBT1_RS13685 2916580..2917074 + 495 WP_003413444.1 DUF2617 family protein -
HKBT1_RS13690 2917071..2917502 + 432 WP_003899390.1 DUF4247 domain-containing protein -
HKBT1_RS13695 2917527..2917985 + 459 WP_003413451.1 DUF350 domain-containing protein -
HKBT1_RS13700 2917982..2919553 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
HKBT1_RS13705 2919664..2919951 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
HKBT1_RS13710 2919938..2920378 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
HKBT1_RS13715 2920399..2921154 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
HKBT1_RS13720 2921287..2921883 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
HKBT1_RS13725 2921891..2922736 - 846 WP_003413466.1 acyl-CoA thioesterase II -
HKBT1_RS13730 2922765..2923664 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
HKBT1_RS13735 2923792..2924466 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T44761 WP_003413460.1 NZ_CP002883:2919938-2920378 [Mycobacterium tuberculosis BT1]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T44761 NZ_CP002883:2919938-2920378 [Mycobacterium tuberculosis BT1]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT44761 WP_003413456.1 NZ_CP002883:2919664-2919951 [Mycobacterium tuberculosis BT1]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT44761 NZ_CP002883:2919664-2919951 [Mycobacterium tuberculosis BT1]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References