Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/- |
Location | 2397115..2397644 | Replicon | chromosome |
Accession | NZ_CP002883 | ||
Organism | Mycobacterium tuberculosis BT1 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TMR4 |
Locus tag | HKBT1_RS11255 | Protein ID | WP_003411124.1 |
Coordinates | 2397115..2397432 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P9WJ74 |
Locus tag | HKBT1_RS11260 | Protein ID | WP_003411127.1 |
Coordinates | 2397429..2397644 (-) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HKBT1_RS11225 | 2392136..2393212 | + | 1077 | WP_003411110.1 | hypothetical protein | - |
HKBT1_RS11230 | 2393209..2393490 | + | 282 | WP_003411112.1 | hypothetical protein | - |
HKBT1_RS11235 | 2393526..2394599 | + | 1074 | WP_003901338.1 | quinone-dependent dihydroorotate dehydrogenase | - |
HKBT1_RS11240 | 2394604..2395134 | - | 531 | WP_003411119.1 | YbhB/YbcL family Raf kinase inhibitor-like protein | - |
HKBT1_RS11245 | 2395182..2396528 | - | 1347 | WP_003411121.1 | M20/M25/M40 family metallo-hydrolase | - |
HKBT1_RS11255 | 2397115..2397432 | - | 318 | WP_003411124.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HKBT1_RS11260 | 2397429..2397644 | - | 216 | WP_003411127.1 | antitoxin ParD2 | Antitoxin |
HKBT1_RS11265 | 2397899..2398957 | + | 1059 | WP_003411129.1 | hypothetical protein | - |
HKBT1_RS11270 | 2399087..2399443 | - | 357 | WP_003411130.1 | hypothetical protein | - |
HKBT1_RS11275 | 2399538..2400320 | - | 783 | WP_003411131.1 | cell wall synthesis protein Wag31 | - |
HKBT1_RS11280 | 2400588..2400878 | - | 291 | WP_003900476.1 | YggT family protein | - |
HKBT1_RS11285 | 2401040..2401696 | - | 657 | WP_003411133.1 | cell division protein SepF | - |
HKBT1_RS11290 | 2401758..2402537 | - | 780 | WP_015575160.1 | YggS family pyridoxal phosphate-dependent enzyme | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12312.88 Da Isoelectric Point: 6.4831
>T44755 WP_003411124.1 NZ_CP002883:c2397432-2397115 [Mycobacterium tuberculosis BT1]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
Download Length: 318 bp
>T44755 NZ_CP002883:c2397432-2397115 [Mycobacterium tuberculosis BT1]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
Antitoxin
Download Length: 72 a.a. Molecular weight: 7880.70 Da Isoelectric Point: 4.4055
>AT44755 WP_003411127.1 NZ_CP002883:c2397644-2397429 [Mycobacterium tuberculosis BT1]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
Download Length: 216 bp
>AT44755 NZ_CP002883:c2397644-2397429 [Mycobacterium tuberculosis BT1]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TMR4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FAJ4 |