Detailed information of TA system TA044754

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2360825..2361520
• Replicon: chromosome
• Accession: NZ_CP002883
• Organism: Mycobacterium tuberculosis BT1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HKBT1_RS11045
• Protein ID: WP_003905754.1
• Coordinates: 2360825..2361259 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: HKBT1_RS11050
• Protein ID: WP_003410814.1
• Coordinates: 2361266..2361520 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKBT1_RS11035	2356979..2360020	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
HKBT1_RS11040	2360013..2360846	+	834	WP_003899172.1	SWIM zinc finger family protein	-
HKBT1_RS11045	2360825..2361259	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
HKBT1_RS11050	2361266..2361520	-	255	WP_003410814.1	antitoxin	Antitoxin
HKBT1_RS11055	2361536..2361793	-	258	WP_003410816.1	hypothetical protein	-
HKBT1_RS11065	2362327..2363588	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
HKBT1_RS11070	2364098..2364394	+	297	WP_003410820.1	PE family protein	-
HKBT1_RS11075	2364450..2365181	+	732	WP_003900467.1	PPE family protein	-
HKBT1_RS11080	2365721..2366467	-	747	WP_003901330.1	proteasome subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T44754 WP_003905754.1 NZ_CP002883:c2361259-2360825 [Mycobacterium tuberculosis BT1]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T44754 NZ_CP002883:c2361259-2360825 [Mycobacterium tuberculosis BT1]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT44754 WP_003410814.1 NZ_CP002883:c2361520-2361266 [Mycobacterium tuberculosis BT1]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT44754 NZ_CP002883:c2361520-2361266 [Mycobacterium tuberculosis BT1]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Antitoxin

• AlphaFold DB: G0TMN0