44751

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2248417..2249043 Replicon chromosome
Accession NZ_CP002883
Organism Mycobacterium tuberculosis BT1

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag HKBT1_RS10535 Protein ID WP_003410075.1
Coordinates 2248645..2249043 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag HKBT1_RS10530 Protein ID WP_003911750.1
Coordinates 2248417..2248644 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT1_RS10520 2246456..2246800 - 345 WP_003410065.1 ferredoxin family protein -
HKBT1_RS10525 2246989..2248158 - 1170 WP_003899126.1 ATP-binding protein -
HKBT1_RS10530 2248417..2248644 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HKBT1_RS10535 2248645..2249043 + 399 WP_003410075.1 PIN domain nuclease Toxin
HKBT1_RS10540 2249226..2249657 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
HKBT1_RS10545 2249758..2250192 + 435 WP_003914358.1 DUF1398 domain-containing protein -
HKBT1_RS21390 2250629..2250808 - 180 Protein_2069 hypothetical protein -
HKBT1_RS10550 2250869..2251516 + 648 WP_078378032.1 transposase -
HKBT1_RS10555 2251470..2252060 + 591 WP_003899131.1 IS110 family transposase -
HKBT1_RS10560 2252188..2253444 - 1257 WP_003902247.1 HNH endonuclease -
HKBT1_RS10565 2253798..2253998 + 201 Protein_2073 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T44751 WP_003410075.1 NZ_CP002883:2248645-2249043 [Mycobacterium tuberculosis BT1]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T44751 NZ_CP002883:2248645-2249043 [Mycobacterium tuberculosis BT1]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT44751 WP_003911750.1 NZ_CP002883:2248417-2248644 [Mycobacterium tuberculosis BT1]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT44751 NZ_CP002883:2248417-2248644 [Mycobacterium tuberculosis BT1]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References