Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2189557..2190101 Replicon chromosome
Accession NZ_CP002883
Organism Mycobacterium tuberculosis BT1

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag HKBT1_RS10205 Protein ID WP_003409896.1
Coordinates 2189557..2189853 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag HKBT1_RS10210 Protein ID WP_003409899.1
Coordinates 2189850..2190101 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT1_RS10150 2184590..2184940 - 351 WP_003409871.1 hypothetical protein -
HKBT1_RS10155 2184951..2185853 - 903 WP_003899097.1 hypothetical protein -
HKBT1_RS10160 2185874..2186065 - 192 WP_003409876.1 hypothetical protein -
HKBT1_RS10165 2186066..2186362 - 297 WP_003409877.1 hypothetical protein -
HKBT1_RS10170 2186602..2186817 + 216 WP_003409878.1 antitoxin -
HKBT1_RS10175 2186814..2187125 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
HKBT1_RS22630 2187099..2187620 - 522 WP_003904745.1 hypothetical protein -
HKBT1_RS10185 2187595..2187972 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
HKBT1_RS10190 2188014..2188463 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
HKBT1_RS10195 2188460..2189005 + 546 WP_003409891.1 SecB-like chaperone -
HKBT1_RS10200 2188894..2189508 - 615 WP_003901296.1 hypothetical protein -
HKBT1_RS10205 2189557..2189853 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKBT1_RS10210 2189850..2190101 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HKBT1_RS10215 2190088..2190582 + 495 WP_003899099.1 hypothetical protein -
HKBT1_RS10220 2190742..2191149 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
HKBT1_RS10225 2191153..2191425 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HKBT1_RS10230 2191458..2192678 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
HKBT1_RS10240 2193577..2194374 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T44747 WP_003409896.1 NZ_CP002883:c2189853-2189557 [Mycobacterium tuberculosis BT1]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T44747 NZ_CP002883:c2189853-2189557 [Mycobacterium tuberculosis BT1]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT44747 WP_003409899.1 NZ_CP002883:c2190101-2189850 [Mycobacterium tuberculosis BT1]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT44747 NZ_CP002883:c2190101-2189850 [Mycobacterium tuberculosis BT1]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References