44738

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1387517..1388076 Replicon chromosome
Accession NZ_CP002883
Organism Mycobacterium tuberculosis BT1

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag HKBT1_RS06590 Protein ID WP_003898789.1
Coordinates 1387517..1387810 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag HKBT1_RS06595 Protein ID WP_003406322.1
Coordinates 1387807..1388076 (-) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT1_RS06565 1383215..1383475 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
HKBT1_RS06570 1383472..1383903 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
HKBT1_RS06575 1383926..1385509 - 1584 WP_009940130.1 PE family protein -
HKBT1_RS06580 1385689..1386549 + 861 WP_003900301.1 hypothetical protein -
HKBT1_RS06585 1386630..1387460 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
HKBT1_RS06590 1387517..1387810 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HKBT1_RS06595 1387807..1388076 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HKBT1_RS06600 1388189..1391884 - 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
HKBT1_RS06605 1392026..1392814 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T44738 WP_003898789.1 NZ_CP002883:c1387810-1387517 [Mycobacterium tuberculosis BT1]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

>T44738 NZ_CP002883:c1387810-1387517 [Mycobacterium tuberculosis BT1]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT44738 WP_003406322.1 NZ_CP002883:c1388076-1387807 [Mycobacterium tuberculosis BT1]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT44738 NZ_CP002883:c1388076-1387807 [Mycobacterium tuberculosis BT1]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0THS1


Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References