Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 753778..754318 | Replicon | chromosome |
Accession | NZ_CP002883 | ||
Organism | Mycobacterium tuberculosis BT1 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P9WII0 |
Locus tag | HKBT1_RS03450 | Protein ID | WP_003403376.1 |
Coordinates | 753778..754086 (-) | Length | 103 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G0TQE0 |
Locus tag | HKBT1_RS03455 | Protein ID | WP_003403381.1 |
Coordinates | 754073..754318 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HKBT1_RS03425 | 749093..750598 | + | 1506 | WP_003403360.1 | carotenoid cleavage oxygenase | - |
HKBT1_RS03430 | 750679..751689 | + | 1011 | WP_003911248.1 | ABC transporter ATP-binding protein | - |
HKBT1_RS03435 | 752077..752460 | - | 384 | WP_003403365.1 | ribonuclease VapC6 | - |
HKBT1_RS03440 | 752555..752710 | - | 156 | WP_003403368.1 | type II toxin-antitoxin system VapB family antitoxin | - |
HKBT1_RS03445 | 752786..753502 | - | 717 | WP_023644507.1 | CPBP family intramembrane metalloprotease | - |
HKBT1_RS03450 | 753778..754086 | - | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
HKBT1_RS03455 | 754073..754318 | - | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
HKBT1_RS03460 | 754428..754865 | - | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | - |
HKBT1_RS03465 | 754862..755116 | - | 255 | WP_003911263.1 | antitoxin VapB7 | - |
HKBT1_RS03470 | 755230..757593 | + | 2364 | WP_003901895.1 | arylsulfatase AtsD | - |
HKBT1_RS03475 | 757656..757982 | + | 327 | WP_003403401.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
HKBT1_RS03480 | 757894..758232 | + | 339 | WP_003403405.1 | PIN domain-containing protein | - |
HKBT1_RS03485 | 758229..758402 | + | 174 | WP_003898549.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11320.10 Da Isoelectric Point: 11.6554
>T44729 WP_003403376.1 NZ_CP002883:c754086-753778 [Mycobacterium tuberculosis BT1]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC
Download Length: 309 bp
>T44729 NZ_CP002883:c754086-753778 [Mycobacterium tuberculosis BT1]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9169.01 Da Isoelectric Point: 4.2070
>AT44729 WP_003403381.1 NZ_CP002883:c754318-754073 [Mycobacterium tuberculosis BT1]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
Download Length: 246 bp
>AT44729 NZ_CP002883:c754318-754073 [Mycobacterium tuberculosis BT1]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSE5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQE0 |