Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2912267..2912981 Replicon chromosome
Accession NZ_CP002882
Organism Mycobacterium tuberculosis BT2

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag HKBT2_RS13685 Protein ID WP_003413460.1
Coordinates 2912541..2912981 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag HKBT2_RS13680 Protein ID WP_003413456.1
Coordinates 2912267..2912554 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT2_RS13645 2907689..2907934 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HKBT2_RS13650 2907931..2908335 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
HKBT2_RS13655 2908552..2909172 + 621 WP_003413441.1 DUF4178 domain-containing protein -
HKBT2_RS13660 2909183..2909677 + 495 WP_003413444.1 DUF2617 family protein -
HKBT2_RS13665 2909674..2910105 + 432 WP_003899390.1 DUF4247 domain-containing protein -
HKBT2_RS13670 2910130..2910588 + 459 WP_003413451.1 DUF350 domain-containing protein -
HKBT2_RS13675 2910585..2912156 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
HKBT2_RS13680 2912267..2912554 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
HKBT2_RS13685 2912541..2912981 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
HKBT2_RS13690 2913002..2913757 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
HKBT2_RS13695 2913890..2914486 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
HKBT2_RS13700 2914494..2915339 - 846 WP_003413466.1 acyl-CoA thioesterase II -
HKBT2_RS13705 2915368..2916267 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
HKBT2_RS13710 2916395..2917069 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T44701 WP_003413460.1 NZ_CP002882:2912541-2912981 [Mycobacterium tuberculosis BT2]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T44701 NZ_CP002882:2912541-2912981 [Mycobacterium tuberculosis BT2]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT44701 WP_003413456.1 NZ_CP002882:2912267-2912554 [Mycobacterium tuberculosis BT2]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT44701 NZ_CP002882:2912267-2912554 [Mycobacterium tuberculosis BT2]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References