Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2388678..2389207 Replicon chromosome
Accession NZ_CP002882
Organism Mycobacterium tuberculosis BT2

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag HKBT2_RS11235 Protein ID WP_003411124.1
Coordinates 2388678..2388995 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag HKBT2_RS11240 Protein ID WP_003411127.1
Coordinates 2388992..2389207 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT2_RS11205 2383699..2384775 + 1077 WP_003411110.1 hypothetical protein -
HKBT2_RS11210 2384772..2385053 + 282 WP_003411112.1 hypothetical protein -
HKBT2_RS11215 2385089..2386162 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
HKBT2_RS11220 2386167..2386697 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
HKBT2_RS11225 2386745..2388091 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
HKBT2_RS11235 2388678..2388995 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKBT2_RS11240 2388992..2389207 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
HKBT2_RS11245 2389462..2390520 + 1059 WP_003411129.1 hypothetical protein -
HKBT2_RS11250 2390650..2391006 - 357 WP_003411130.1 hypothetical protein -
HKBT2_RS11255 2391101..2391883 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
HKBT2_RS11260 2392151..2392441 - 291 WP_003900476.1 YggT family protein -
HKBT2_RS11265 2392603..2393259 - 657 WP_003411133.1 cell division protein SepF -
HKBT2_RS11270 2393321..2394100 - 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T44695 WP_003411124.1 NZ_CP002882:c2388995-2388678 [Mycobacterium tuberculosis BT2]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T44695 NZ_CP002882:c2388995-2388678 [Mycobacterium tuberculosis BT2]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT44695 WP_003411127.1 NZ_CP002882:c2389207-2388992 [Mycobacterium tuberculosis BT2]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT44695 NZ_CP002882:c2389207-2388992 [Mycobacterium tuberculosis BT2]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References