Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2182770..2183314 Replicon chromosome
Accession NZ_CP002882
Organism Mycobacterium tuberculosis BT2

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag HKBT2_RS10180 Protein ID WP_003409896.1
Coordinates 2182770..2183066 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag HKBT2_RS10185 Protein ID WP_003409899.1
Coordinates 2183063..2183314 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT2_RS10125 2177803..2178153 - 351 WP_003409871.1 hypothetical protein -
HKBT2_RS10130 2178164..2179066 - 903 WP_003899097.1 hypothetical protein -
HKBT2_RS10135 2179087..2179278 - 192 WP_003409876.1 hypothetical protein -
HKBT2_RS10140 2179279..2179575 - 297 WP_003409877.1 hypothetical protein -
HKBT2_RS10145 2179815..2180030 + 216 WP_003409878.1 antitoxin -
HKBT2_RS10150 2180027..2180338 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
HKBT2_RS22570 2180312..2180833 - 522 WP_003904745.1 hypothetical protein -
HKBT2_RS10160 2180808..2181185 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
HKBT2_RS10165 2181227..2181676 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
HKBT2_RS10170 2181673..2182218 + 546 WP_003409891.1 SecB-like chaperone -
HKBT2_RS10175 2182107..2182721 - 615 WP_003901296.1 hypothetical protein -
HKBT2_RS10180 2182770..2183066 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKBT2_RS10185 2183063..2183314 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HKBT2_RS10190 2183301..2183795 + 495 WP_003899099.1 hypothetical protein -
HKBT2_RS10195 2183955..2184362 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
HKBT2_RS10200 2184366..2184638 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HKBT2_RS10205 2184671..2185891 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
HKBT2_RS10215 2186790..2187587 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T44687 WP_003409896.1 NZ_CP002882:c2183066-2182770 [Mycobacterium tuberculosis BT2]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T44687 NZ_CP002882:c2183066-2182770 [Mycobacterium tuberculosis BT2]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT44687 WP_003409899.1 NZ_CP002882:c2183314-2183063 [Mycobacterium tuberculosis BT2]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT44687 NZ_CP002882:c2183314-2183063 [Mycobacterium tuberculosis BT2]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References