Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1013389..1014008 Replicon chromosome
Accession NZ_CP002882
Organism Mycobacterium tuberculosis BT2

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag HKBT2_RS04780 Protein ID WP_003404726.1
Coordinates 1013574..1014008 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag HKBT2_RS04775 Protein ID WP_003898641.1
Coordinates 1013389..1013568 (+) Length 60 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT2_RS04765 1008862..1010442 + 1581 WP_003910977.1 serine hydrolase -
HKBT2_RS04770 1010439..1012832 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
HKBT2_RS22475 1013105..1013263 + 159 WP_003404720.1 hypothetical protein -
HKBT2_RS04775 1013389..1013568 + 180 WP_003898641.1 antitoxin Antitoxin
HKBT2_RS04780 1013574..1014008 + 435 WP_003404726.1 SRPBCC family protein Toxin
HKBT2_RS04785 1014106..1014879 + 774 WP_003404735.1 VOC family protein -
HKBT2_RS04790 1014944..1015393 + 450 WP_003404738.1 hypothetical protein -
HKBT2_RS04795 1015528..1015758 - 231 WP_003898642.1 hypothetical protein -
HKBT2_RS04800 1015925..1017433 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
HKBT2_RS04805 1017435..1018673 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin

(4-50)


Sequences


Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T44673 WP_003404726.1 NZ_CP002882:1013574-1014008 [Mycobacterium tuberculosis BT2]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T44673 NZ_CP002882:1013574-1014008 [Mycobacterium tuberculosis BT2]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT44673 WP_003898641.1 NZ_CP002882:1013389-1013568 [Mycobacterium tuberculosis BT2]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT44673 NZ_CP002882:1013389-1013568 [Mycobacterium tuberculosis BT2]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References