44652

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3763129..3763658 Replicon chromosome
Accession NZ_CP002871
Organism Mycobacterium tuberculosis HKBS1

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag HKBS1_RS17715 Protein ID WP_003417760.1
Coordinates 3763401..3763658 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag HKBS1_RS17710 Protein ID WP_003417757.1
Coordinates 3763129..3763404 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBS1_RS22660 3759927..3761364 - 1438 Protein_3463 FAD-binding oxidoreductase -
HKBS1_RS17695 3761467..3761856 + 390 WP_003417745.1 DUF732 domain-containing protein -
HKBS1_RS17700 3761870..3762163 - 294 WP_003417749.1 DUF3017 domain-containing protein -
HKBS1_RS17705 3762160..3763005 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
HKBS1_RS17710 3763129..3763404 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
HKBS1_RS17715 3763401..3763658 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
HKBS1_RS17720 3763700..3764890 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
HKBS1_RS17725 3765007..3765375 + 369 WP_003417765.1 FHA domain-containing protein -
HKBS1_RS17730 3765372..3765923 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
HKBS1_RS17735 3765930..3766511 - 582 WP_003417769.1 ATP/GTP-binding protein -
HKBS1_RS17740 3766492..3766860 - 369 WP_003417772.1 DUF742 domain-containing protein -
HKBS1_RS17745 3766838..3767230 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T44652 WP_003417760.1 NZ_CP002871:3763401-3763658 [Mycobacterium tuberculosis HKBS1]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T44652 NZ_CP002871:3763401-3763658 [Mycobacterium tuberculosis HKBS1]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT44652 WP_003417757.1 NZ_CP002871:3763129-3763404 [Mycobacterium tuberculosis HKBS1]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT44652 NZ_CP002871:3763129-3763404 [Mycobacterium tuberculosis HKBS1]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References