44639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2860574..2861205 Replicon chromosome
Accession NZ_CP002871
Organism Mycobacterium tuberculosis HKBS1

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag HKBS1_RS13440 Protein ID WP_003413174.1
Coordinates 2860828..2861205 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag HKBS1_RS13435 Protein ID WP_003413167.1
Coordinates 2860574..2860831 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBS1_RS13410 2856489..2856803 + 315 WP_009937839.1 hypothetical protein -
HKBS1_RS13415 2857099..2858310 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
HKBS1_RS13420 2858437..2859096 + 660 WP_003902296.1 hypothetical protein -
HKBS1_RS13425 2859093..2859755 + 663 WP_003905878.1 hypothetical protein -
HKBS1_RS22230 2859752..2860029 + 278 Protein_2626 type II toxin-antitoxin system VapB family antitoxin -
HKBS1_RS13430 2860122..2860535 + 414 WP_003413164.1 PIN domain nuclease -
HKBS1_RS13435 2860574..2860831 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
HKBS1_RS13440 2860828..2861205 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
HKBS1_RS13445 2861221..2861595 - 375 WP_003413177.1 hypothetical protein -
HKBS1_RS13450 2861695..2862090 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
HKBS1_RS13455 2862087..2862332 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
HKBS1_RS13460 2862743..2863162 - 420 WP_003413190.1 A24 family peptidase -
HKBS1_RS13465 2863174..2863983 - 810 WP_003413193.1 shikimate dehydrogenase -
HKBS1_RS13470 2863980..2865233 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
HKBS1_RS13475 2865226..2865738 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T44639 WP_003413174.1 NZ_CP002871:2860828-2861205 [Mycobacterium tuberculosis HKBS1]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T44639 NZ_CP002871:2860828-2861205 [Mycobacterium tuberculosis HKBS1]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT44639 WP_003413167.1 NZ_CP002871:2860574-2860831 [Mycobacterium tuberculosis HKBS1]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT44639 NZ_CP002871:2860574-2860831 [Mycobacterium tuberculosis HKBS1]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References