Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2188827..2189371 | Replicon | chromosome |
| Accession | NZ_CP002871 | ||
| Organism | Mycobacterium tuberculosis HKBS1 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | HKBS1_RS10195 | Protein ID | WP_003409896.1 |
| Coordinates | 2188827..2189123 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | HKBS1_RS10200 | Protein ID | WP_003409899.1 |
| Coordinates | 2189120..2189371 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HKBS1_RS10140 | 2183860..2184210 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| HKBS1_RS10145 | 2184221..2185123 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| HKBS1_RS10150 | 2185144..2185335 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| HKBS1_RS10155 | 2185336..2185632 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| HKBS1_RS10160 | 2185872..2186087 | + | 216 | WP_003409878.1 | antitoxin | - |
| HKBS1_RS10165 | 2186084..2186395 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| HKBS1_RS22555 | 2186369..2186890 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| HKBS1_RS10175 | 2186865..2187242 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| HKBS1_RS10180 | 2187284..2187733 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| HKBS1_RS10185 | 2187730..2188275 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| HKBS1_RS10190 | 2188164..2188778 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| HKBS1_RS10195 | 2188827..2189123 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HKBS1_RS10200 | 2189120..2189371 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| HKBS1_RS10205 | 2189358..2189852 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| HKBS1_RS10210 | 2190012..2190419 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| HKBS1_RS10215 | 2190423..2190695 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HKBS1_RS10220 | 2190728..2191948 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| HKBS1_RS10230 | 2192847..2193644 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T44627 WP_003409896.1 NZ_CP002871:c2189123-2188827 [Mycobacterium tuberculosis HKBS1]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T44627 NZ_CP002871:c2189123-2188827 [Mycobacterium tuberculosis HKBS1]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT44627 WP_003409899.1 NZ_CP002871:c2189371-2189120 [Mycobacterium tuberculosis HKBS1]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT44627 NZ_CP002871:c2189371-2189120 [Mycobacterium tuberculosis HKBS1]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |