44623

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1939773..1940386 Replicon chromosome
Accession NZ_CP002871
Organism Mycobacterium tuberculosis HKBS1

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag HKBS1_RS09015 Protein ID WP_003408465.1
Coordinates 1939773..1940162 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag HKBS1_RS09020 Protein ID WP_003408469.1
Coordinates 1940159..1940386 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBS1_RS08985 1935402..1936316 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
HKBS1_RS08990 1936319..1937149 + 831 WP_003408448.1 cyclase family protein -
HKBS1_RS08995 1937149..1937499 + 351 WP_003898986.1 cupin domain-containing protein -
HKBS1_RS09000 1937552..1938370 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
HKBS1_RS09005 1938384..1939163 + 780 WP_003408460.1 IclR family transcriptional regulator -
HKBS1_RS09015 1939773..1940162 - 390 WP_003408465.1 PIN domain-containing protein Toxin
HKBS1_RS09020 1940159..1940386 - 228 WP_003408469.1 antitoxin Antitoxin
HKBS1_RS09025 1940604..1942088 + 1485 WP_003408473.1 carboxylase -
HKBS1_RS09030 1942085..1943332 + 1248 WP_003408476.1 serine hydrolase -
HKBS1_RS09035 1943375..1943794 - 420 WP_003408483.1 hypothetical protein -
HKBS1_RS09040 1943784..1944494 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T44623 WP_003408465.1 NZ_CP002871:c1940162-1939773 [Mycobacterium tuberculosis HKBS1]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T44623 NZ_CP002871:c1940162-1939773 [Mycobacterium tuberculosis HKBS1]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT44623 WP_003408469.1 NZ_CP002871:c1940386-1940159 [Mycobacterium tuberculosis HKBS1]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT44623 NZ_CP002871:c1940386-1940159 [Mycobacterium tuberculosis HKBS1]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References