Detailed information of TA system TA044617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1382951..1383639
• Replicon: chromosome
• Accession: NZ_CP002871
• Organism: Mycobacterium tuberculosis HKBS1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: HKBS1_RS06575
• Protein ID: WP_003406304.1
• Coordinates: 1383208..1383639 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: HKBS1_RS06570
• Protein ID: WP_003406302.1
• Coordinates: 1382951..1383211 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKBS1_RS06550	1378528..1379352	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
HKBS1_RS06555	1379357..1380538	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
HKBS1_RS06560	1380615..1381715	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
HKBS1_RS06565	1381886..1382875	+	990	WP_003406301.1	malate dehydrogenase	-
HKBS1_RS06570	1382951..1383211	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
HKBS1_RS06575	1383208..1383639	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
HKBS1_RS06580	1383662..1385245	-	1584	WP_009940130.1	PE family protein	-
HKBS1_RS06585	1385425..1386285	+	861	WP_003900301.1	hypothetical protein	-
HKBS1_RS06590	1386366..1387196	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
HKBS1_RS06595	1387253..1387546	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
HKBS1_RS06600	1387543..1387812	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T44617 WP_003406304.1 NZ_CP002871:1383208-1383639 [Mycobacterium tuberculosis HKBS1]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T44617 NZ_CP002871:1383208-1383639 [Mycobacterium tuberculosis HKBS1]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT44617 WP_003406302.1 NZ_CP002871:1382951-1383211 [Mycobacterium tuberculosis HKBS1]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT44617 NZ_CP002871:1382951-1383211 [Mycobacterium tuberculosis HKBS1]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6