Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 534539..536221 Replicon chromosome
Accession NZ_CP002581
Organism Burkholderia plantarii strain PG1

Toxin (Protein)


Gene name hipA Uniprot ID A0A0B6RT63
Locus tag BGL_RS20070 Protein ID WP_042627153.1
Coordinates 534539..535873 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0B6RYR1
Locus tag BGL_RS20075 Protein ID WP_052498396.1
Coordinates 535880..536221 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGL_RS20060 529717..532902 + 3186 WP_042627151.1 multidrug efflux RND transporter permease subunit -
BGL_RS20065 532914..534458 + 1545 WP_042627152.1 efflux transporter outer membrane subunit -
BGL_RS20070 534539..535873 - 1335 WP_042627153.1 type II toxin-antitoxin system HipA family toxin Toxin
BGL_RS20075 535880..536221 - 342 WP_052498396.1 helix-turn-helix domain-containing protein Antitoxin
BGL_RS20080 536357..537286 - 930 WP_042627154.1 spherulation-specific family 4 protein -
BGL_RS20085 537718..538917 + 1200 WP_042627155.1 acyl-CoA dehydrogenase family protein -
BGL_RS20090 538967..539470 - 504 WP_042627156.1 hypothetical protein -
BGL_RS20095 539756..540499 - 744 WP_042629249.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(157-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 48579.63 Da        Isoelectric Point: 8.1050

>T44595 WP_042627153.1 NZ_CP002581:c535873-534539 [Burkholderia plantarii]
MPRTSHATRLALWMNGIEVGYWERIQGVDRLAYAPGWLDHPQRRPLSLSLPFRPGNLPYQGAAVANYFDNLLPDSDAIRR
RLAQRHAARDTTPFALLEAVGRDCVGALQLLPEGHAPAGLKRIAGTPLDEAAIAQWLRALPLVAGTGRDSASHDLRLSIA
GAQEKTALLWHDGQWLRPEGSTPTTHILKLPLGLVAGLGADLRTSVENEWLCALLVAAYGLPVAPCGIGRFEDQKALVVE
RFDRRPSADGNWLVRLPQEDLCQATGTSGLNKYEADGGPGIDAVMDLLAGSIDAALDRRHFFTTQLVFWLLAAADGHGKN
FSIAHLPEARYRATPLYDVLSFHPILGRRAGQIAPQRLRMAMAVRGTHKHYGWQEIRTRHWIAQGRRCGLGEQTVRALIG
ELVAATPRVIDEVAALLPADFPADLADAIFTGLRTQARQMETGL

Download         Length: 1335 bp

>T44595 NZ_CP002581:c535873-534539 [Burkholderia plantarii]
ATGCCACGCACCTCTCACGCCACGCGCCTCGCGCTCTGGATGAACGGCATCGAGGTCGGCTACTGGGAGCGGATCCAGGG
CGTCGATCGCCTCGCTTACGCACCGGGCTGGCTCGACCATCCGCAACGCCGCCCGCTGTCCCTGTCGCTGCCGTTCCGCC
CCGGCAATCTGCCTTATCAGGGCGCCGCCGTCGCGAATTACTTCGACAACCTGCTGCCCGACAGCGACGCGATTCGCCGC
CGCCTCGCGCAGCGTCACGCGGCGCGCGACACCACGCCGTTCGCGCTGCTCGAGGCGGTGGGGCGCGACTGCGTCGGCGC
CCTGCAACTGTTGCCGGAAGGCCATGCGCCCGCCGGCCTGAAACGGATCGCGGGTACGCCGCTCGACGAGGCCGCGATCG
CGCAATGGCTGCGCGCGCTGCCGCTCGTCGCGGGCACCGGTCGCGACTCGGCCAGCCATGACCTGCGCCTGTCGATCGCC
GGCGCGCAGGAGAAAACCGCGCTGCTCTGGCACGACGGCCAATGGCTGCGCCCCGAAGGCAGCACGCCCACCACGCACAT
TCTCAAGCTGCCGCTCGGCCTCGTGGCCGGCCTCGGCGCCGACCTGCGCACCTCGGTCGAGAACGAATGGCTCTGCGCGC
TGCTGGTGGCCGCCTACGGGCTGCCCGTCGCGCCGTGCGGCATCGGCCGGTTCGAGGATCAAAAGGCGCTCGTGGTCGAA
CGTTTCGACCGGCGCCCCTCGGCCGACGGCAACTGGCTCGTGCGCCTGCCGCAGGAGGATTTGTGCCAGGCCACCGGCAC
GTCGGGCCTGAACAAATACGAAGCCGACGGCGGCCCCGGCATCGATGCGGTCATGGACCTCCTGGCCGGCTCGATCGACG
CGGCGCTCGACCGGCGCCACTTCTTCACGACACAACTGGTGTTCTGGCTGCTCGCGGCCGCCGACGGCCACGGCAAGAAT
TTCAGCATCGCGCATCTGCCCGAAGCACGTTATCGGGCCACGCCGCTCTACGATGTCCTGTCGTTTCATCCGATCCTGGG
GCGCCGCGCCGGACAGATCGCGCCGCAGCGCCTGCGCATGGCGATGGCCGTGCGCGGTACGCACAAGCATTACGGCTGGC
AGGAAATCCGCACGCGCCACTGGATCGCGCAGGGGCGCCGCTGCGGTTTGGGCGAGCAGACGGTGCGCGCGCTGATCGGC
GAACTCGTGGCCGCGACGCCGCGCGTGATCGACGAGGTCGCGGCGCTGCTGCCGGCCGACTTCCCCGCCGACCTCGCCGA
CGCGATCTTCACCGGCCTGCGCACGCAGGCCCGTCAAATGGAAACGGGCCTCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 11902.51 Da        Isoelectric Point: 10.2944

>AT44595 WP_052498396.1 NZ_CP002581:c536221-535880 [Burkholderia plantarii]
VDYPVKTPAQLRPLLQGFRKAAGLTQAAMAERLGVTQQTYARLEADPTRASVERLFRVMRVLGIEMKLGGAAPAAAEPHA
GHAVPPSSSATATEPAAPTAGGRRGSDTPREDW

Download         Length: 342 bp

>AT44595 NZ_CP002581:c536221-535880 [Burkholderia plantarii]
GTGGACTATCCCGTCAAGACACCCGCCCAGTTGCGCCCCCTGCTGCAAGGTTTCCGCAAGGCGGCAGGGCTCACGCAGGC
CGCCATGGCCGAACGGCTCGGCGTCACGCAGCAGACCTACGCCCGCCTCGAAGCCGATCCGACCCGCGCGAGCGTCGAAC
GGCTGTTCCGCGTGATGCGCGTGCTCGGCATCGAAATGAAGCTGGGCGGCGCCGCGCCGGCAGCGGCCGAACCGCATGCC
GGCCATGCCGTCCCGCCGTCTTCATCGGCCACCGCCACCGAACCCGCCGCCCCCACGGCCGGCGGCCGGCGCGGCAGCGA
TACGCCCCGCGAGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B6RT63

Antitoxin

Source ID Structure
AlphaFold DB A0A0B6RYR1

References