Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 144350..146127 Replicon chromosome
Accession NZ_CP002581
Organism Burkholderia plantarii strain PG1

Toxin (Protein)


Gene name doc Uniprot ID A0A0B6S1E4
Locus tag BGL_RS18505 Protein ID WP_042626899.1
Coordinates 144350..145270 (+) Length 307 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0B6S4I7
Locus tag BGL_RS18510 Protein ID WP_042626900.1
Coordinates 145267..146127 (+) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGL_RS18480 139385..140344 + 960 WP_042629201.1 PDR/VanB family oxidoreductase -
BGL_RS18485 140490..141464 + 975 WP_042626896.1 IclR family transcriptional regulator -
BGL_RS18490 141524..142597 - 1074 WP_042626897.1 porin -
BGL_RS18495 142993..143763 + 771 WP_042626898.1 SDR family oxidoreductase -
BGL_RS18500 143800..144339 + 540 WP_042629202.1 cupin domain-containing protein -
BGL_RS18505 144350..145270 + 921 WP_042626899.1 alpha/beta hydrolase Toxin
BGL_RS18510 145267..146127 + 861 WP_042626900.1 IclR family transcriptional regulator Antitoxin
BGL_RS18515 146128..146943 + 816 WP_042626901.1 SDR family oxidoreductase -
BGL_RS18520 146936..148594 + 1659 WP_042626902.1 thiamine pyrophosphate-binding protein -
BGL_RS18525 148587..149414 + 828 WP_042626903.1 aspartate dehydrogenase -
BGL_RS18530 149430..150926 + 1497 WP_042626904.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(57-286)

Antitoxin

Transcription regulator IclR, N-terminal

(26-74)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 31204.49 Da        Isoelectric Point: 7.2359

>T44594 WP_042626899.1 NZ_CP002581:144350-145270 [Burkholderia plantarii]
MHDHPSHAGPTDGAPDLGARLPAFPARRIDVAPARAVGYREAGAPPAAGPHAGRLPIVLLHGIGSGAASWVQQLDTLGAA
RRVLAWDAPGYGESSPVAPASPQAGDYAAVLADWLDALGVARCVLVGHSLGAIVAGRFAATHGARVAGLLLLSPAAGYGA
ASEAVRAQKRDARLAMLAELGPQGLAERRSANMLSPSASEPARQWVRWNMARVVPAGYAQATHLLANADLAADLAGRRGP
VMVAVGEHDGITPPEACARLARAAGVLLQLIPNAGHAGYIEAPAACDALIDAFARRCETPDPEASA

Download         Length: 921 bp

>T44594 NZ_CP002581:144350-145270 [Burkholderia plantarii]
ATGCACGACCACCCCAGCCACGCCGGCCCGACCGACGGCGCGCCGGACCTCGGCGCCCGGCTCCCGGCGTTCCCCGCGCG
GCGGATCGACGTGGCGCCGGCGCGCGCCGTCGGCTATCGAGAAGCCGGCGCGCCGCCTGCCGCCGGCCCGCATGCCGGCC
GCCTGCCGATCGTGCTGCTGCACGGCATCGGCTCCGGCGCGGCGTCGTGGGTGCAGCAGCTCGACACGCTCGGCGCCGCG
CGCCGCGTGCTCGCCTGGGATGCGCCGGGCTACGGCGAATCGAGCCCGGTCGCGCCGGCCTCCCCGCAGGCCGGCGACTA
CGCCGCCGTGCTGGCGGACTGGCTCGACGCGCTCGGCGTCGCGCGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCG
TCGCCGGCCGCTTCGCCGCCACGCATGGCGCGCGCGTCGCGGGCCTGCTGCTGCTGTCGCCCGCGGCCGGCTACGGCGCC
GCGAGCGAGGCGGTGCGCGCGCAGAAGCGCGACGCGCGCCTCGCGATGCTGGCCGAACTCGGCCCGCAGGGGCTCGCCGA
GCGGCGCAGCGCCAACATGCTGTCGCCGTCCGCGAGCGAGCCGGCCCGGCAATGGGTGCGCTGGAACATGGCGCGCGTCG
TGCCGGCCGGCTACGCGCAGGCCACGCACCTGCTGGCCAACGCGGATCTGGCCGCCGATCTGGCGGGCCGTCGCGGGCCG
GTGATGGTGGCGGTCGGCGAGCACGACGGCATCACGCCGCCCGAAGCCTGCGCGCGCCTCGCGCGGGCGGCGGGCGTGCT
GCTGCAACTGATCCCGAACGCCGGCCACGCCGGCTACATCGAGGCGCCGGCGGCCTGCGACGCGCTGATCGACGCGTTCG
CGCGGCGTTGCGAGACGCCGGACCCGGAGGCGAGCGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 30995.41 Da        Isoelectric Point: 6.7787

>AT44594 WP_042626900.1 NZ_CP002581:145267-146127 [Burkholderia plantarii]
MTPASTDRAAPDAPAQGEVSYLVPGLDRGLRILTEFSAREPILGAPELSRRLGIPRTTVFRLLQTLESLGFIERANGERN
YRLGVAVLRLGFEFLSSLELTDLGLPLIEALRDSTGLSTHIVIRDGRDVVFVAKAQSHASAFSAVKVNVGTRLPAHATTH
GHVLMGDLTLDELRALYAGVTLERFTRHTPGTVDELFERVRADAEQGHAISESSFEHGISVVSAPVFGDAGRIVAVVTAT
VPRAHFDTTLPAVDLIGKVRAAAFQLSLRLNYRPPAETRFMNALEI

Download         Length: 861 bp

>AT44594 NZ_CP002581:145267-146127 [Burkholderia plantarii]
ATGACGCCGGCATCGACCGACCGCGCCGCGCCGGATGCCCCGGCGCAGGGCGAAGTCAGCTATCTGGTGCCCGGGCTCGA
TCGCGGGCTGCGCATCCTCACCGAATTCTCGGCACGCGAGCCGATCCTGGGCGCGCCGGAGCTGTCGCGCCGGCTCGGCA
TTCCGCGCACCACGGTGTTCCGGCTGCTGCAGACGCTCGAATCGCTCGGCTTCATCGAGCGCGCCAACGGCGAGCGCAAT
TACCGGCTCGGCGTGGCGGTGTTGCGGCTCGGCTTCGAATTCCTCAGTTCGCTGGAGCTGACCGACCTGGGCCTGCCGCT
GATCGAGGCGCTGCGCGACAGCACCGGCCTGTCCACCCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCCA
AGGCGCAGAGCCACGCGAGCGCGTTCAGCGCGGTGAAGGTCAACGTCGGCACGCGGCTGCCCGCCCACGCCACCACCCAC
GGCCACGTGCTGATGGGCGACCTGACGCTCGACGAACTGCGCGCGCTGTATGCGGGCGTCACGCTGGAACGCTTCACGCG
GCATACGCCCGGCACCGTCGACGAGCTGTTCGAGCGCGTGCGCGCCGACGCCGAGCAGGGCCACGCGATCAGCGAATCGT
CGTTCGAACACGGCATTTCGGTGGTCAGCGCGCCGGTGTTCGGCGACGCGGGGCGGATCGTGGCGGTGGTCACGGCCACG
GTGCCGCGCGCGCATTTCGACACCACGCTGCCCGCCGTCGACCTGATCGGCAAGGTGCGGGCGGCCGCGTTTCAACTCTC
GCTGCGGCTCAACTACCGGCCGCCGGCGGAAACCCGCTTCATGAATGCTTTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B6S1E4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B6S4I7

References