Detailed information of TA system TA044593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1980978..1981543
• Replicon: chromosome
• Accession: NZ_CP002580
• Organism: Burkholderia plantarii strain PG1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0B6RS57
• Locus tag: BGL_RS08510
• Protein ID: WP_042624789.1
• Coordinates: 1981172..1981543 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BGL_RS33635
• Protein ID: WP_080937153.1
• Coordinates: 1980978..1981175 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BGL_RS33625	1976695..1977600	-	906	WP_158336050.1	GIY-YIG nuclease family protein	-
BGL_RS08495	1978971..1979570	+	600	WP_123863476.1	hypothetical protein	-
BGL_RS08500	1979572..1980360	+	789	WP_042624788.1	antirepressor	-
BGL_RS08505	1980466..1980754	+	289	Protein_1722	hypothetical protein	-
BGL_RS33635	1980978..1981175	+	198	WP_080937153.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BGL_RS08510	1981172..1981543	+	372	WP_042624789.1	type II toxin-antitoxin system VapC family toxin	Toxin
BGL_RS33640	1981648..1981899	+	252	WP_080937154.1	hypothetical protein	-
BGL_RS33645	1981917..1983041	+	1125	WP_080937155.1	ATP-binding protein	-
BGL_RS32830	1983163..1983984	+	822	WP_052498296.1	hypothetical protein	-
BGL_RS08525	1983993..1984781	+	789	WP_063931946.1	hypothetical protein	-
BGL_RS08530	1984778..1985266	+	489	WP_042624791.1	hypothetical protein	-
BGL_RS08535	1985277..1985615	+	339	WP_042624792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1946088..2068788	122700

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-113)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13611.92 Da
• Isoelectric Point: 5.1259

>T44593 WP_042624789.1 NZ_CP002580:1981172-1981543 [Burkholderia plantarii]
MILVDTSVWIDHINTADPMLIALLAEERVLIHPYVIGEISLGSLRNRDIVLGALLDLPHAAVATPDETFFLIEREGLFNR
GVGYVDVSLLASARLMPGVTVWTRDKRLKNLAEELRLGAMLGH

Nucleotide

• Length: 372 bp

>T44593 NZ_CP002580:1981172-1981543 [Burkholderia plantarii]
ATGATCCTCGTTGACACCTCGGTTTGGATCGACCACATCAATACTGCCGATCCGATGCTGATAGCGTTGCTTGCCGAGGA
GCGCGTTCTGATCCATCCCTACGTGATTGGGGAGATTTCACTCGGCAGCTTGCGCAATCGCGACATCGTGCTTGGCGCAT
TGCTGGATTTGCCTCACGCTGCAGTTGCAACGCCGGATGAGACGTTCTTTCTAATTGAACGTGAGGGCTTGTTCAATAGG
GGCGTCGGGTATGTGGACGTCTCTCTGCTAGCTTCGGCCCGTCTCATGCCAGGCGTCACCGTCTGGACACGCGACAAGCG
TTTAAAGAATCTCGCTGAGGAACTTCGCCTCGGTGCAATGCTTGGGCACTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7108.15 Da
• Isoelectric Point: 10.3509

>AT44593 WP_080937153.1 NZ_CP002580:1980978-1981175 [Burkholderia plantarii]
MRTTIALDDDLIAKAQAYTGVEEKSALVREALKALIQREAAKRLANLGGSQPGIKSVSRRRQDVE

Nucleotide

• Length: 198 bp

>AT44593 NZ_CP002580:1980978-1981175 [Burkholderia plantarii]
ATGCGCACCACTATTGCCCTTGACGACGACTTGATCGCCAAAGCCCAAGCATATACGGGCGTGGAGGAAAAATCCGCGCT
TGTGCGCGAGGCACTGAAGGCACTGATACAGCGCGAGGCCGCAAAACGCTTGGCAAATCTCGGGGGGAGTCAACCGGGCA
TCAAAAGCGTGTCGCGTCGACGACAGGATGTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0B6RS57