Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1298763..1299249 Replicon chromosome
Accession NZ_CP002007
Organism Streptococcus suis 05HAS68

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag HAS68_RS06540 Protein ID WP_002935012.1
Coordinates 1298992..1299249 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag HAS68_RS06535 Protein ID WP_002935014.1
Coordinates 1298763..1299002 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAS68_RS11590 1294412..1294549 + 138 WP_002935027.1 hypothetical protein -
HAS68_RS06510 1294562..1295296 + 735 WP_002935025.1 beta-carotene 15,15'-monooxygenase -
HAS68_RS11595 1295395..1295535 + 141 WP_002935023.1 hypothetical protein -
HAS68_RS06520 1295548..1295931 + 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
HAS68_RS06525 1295948..1296700 + 753 WP_002935019.1 ABC transporter ATP-binding protein -
HAS68_RS06530 1296701..1298671 + 1971 WP_013730363.1 FtsX-like permease family protein -
HAS68_RS06535 1298763..1299002 + 240 WP_002935014.1 hypothetical protein Antitoxin
HAS68_RS06540 1298992..1299249 + 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HAS68_RS06545 1299288..1299953 + 666 WP_009909826.1 response regulator transcription factor -
HAS68_RS06550 1299950..1300891 + 942 WP_002935009.1 sensor histidine kinase -
HAS68_RS06555 1300967..1302475 + 1509 WP_013730362.1 phosphoglucomutase -
HAS68_RS06560 1302545..1303615 - 1071 WP_002935006.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1217453..1303615 86162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T44591 WP_002935012.1 NZ_CP002007:1298992-1299249 [Streptococcus suis 05HAS68]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T44591 NZ_CP002007:1298992-1299249 [Streptococcus suis 05HAS68]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT44591 WP_002935014.1 NZ_CP002007:1298763-1299002 [Streptococcus suis 05HAS68]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT44591 NZ_CP002007:1298763-1299002 [Streptococcus suis 05HAS68]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References