Detailed information of TA system TA044590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1215908..1217178
• Replicon: chromosome
• Accession: NZ_CP002007
• Organism: Streptococcus suis 05HAS68

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z8INM2
• Locus tag: HAS68_RS06160
• Protein ID: WP_024409332.1
• Coordinates: 1216384..1217178 (+)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: HAS68_RS06155
• Protein ID: WP_024409333.1
• Coordinates: 1215908..1216384 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAS68_RS06115	1211368..1212279	+	912	WP_032505215.1	hypothetical protein	-
HAS68_RS06120	1212349..1212648	+	300	WP_024382151.1	hypothetical protein	-
HAS68_RS06125	1212663..1212953	+	291	WP_024409338.1	hypothetical protein	-
HAS68_RS06130	1213064..1213702	+	639	WP_024409337.1	hypothetical protein	-
HAS68_RS06135	1213742..1214830	+	1089	WP_024409336.1	toprim domain-containing protein	-
HAS68_RS06140	1214884..1215111	+	228	WP_024409335.1	hypothetical protein	-
HAS68_RS06145	1215115..1215510	+	396	WP_017285409.1	hypothetical protein	-
HAS68_RS06150	1215554..1215838	+	285	WP_024409334.1	hypothetical protein	-
HAS68_RS06155	1215908..1216384	+	477	WP_024409333.1	helix-turn-helix domain-containing protein	Antitoxin
HAS68_RS06160	1216384..1217178	+	795	WP_024409332.1	zeta toxin family protein	Toxin
HAS68_RS06165	1217159..1217362	+	204	Protein_1169	AAA family ATPase	-
HAS68_RS06170	1217453..1218397	+	945	WP_024409330.1	IS30 family transposase	-
HAS68_RS06175	1218405..1220228	+	1824	Protein_1171	AAA family ATPase	-
HAS68_RS06180	1220225..1222150	+	1926	WP_024409328.1	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 30360.57 Da
• Isoelectric Point: 6.6151

>T44590 WP_024409332.1 NZ_CP002007:1216384-1217178 [Streptococcus suis 05HAS68]
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN

Nucleotide

• Length: 795 bp

>T44590 NZ_CP002007:1216384-1217178 [Streptococcus suis 05HAS68]
ATGCGGTTAGAAGAATTTAGCAAAGATGACTTTGACTTAGCCTTAAAACGAACTATTCGTTCCTTAACTCGTGGTAAAAC
GACATCAGTTACCCCAAAAGCCATCTTACTTGGTGGGCAAAGTGGAGCAGGAAAAACAACGATACACCGTATCAAGCAGA
AAGAGTTCCAAGGTAATATTATCATTATTGACGGTGATAGCTACCGCTCTTTACACCCGAATTATCTAACTTTACAAGAA
GAGTACGGGAAGGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGTGGAACAGCTTGTGGATGAACTCAGTAA
ACAAGGTTATCATTTGTTAATCGAAGGAACTTTGAGAACGACAGAAGTCCCACGAAAAACAGCACGGCTATTGAAAGCGA
GAGGTTATCAAGTCTCATTAGCTTTGATAGCAACCAAGCCTGAATTGTCTTATCTCAGCACCTTAATCCGCTACGAAGAA
GTCTATGTGGTTAATCCAAACCAAGCTAGAGCAACTCCTAAAGAACATCATGATGGAATTGTCAATCACTTGGTTGATAA
CTTACGAGAGCTAGAAAACGACCATCTCTTTGATTATATTCAAATTTATCAAAGAGATAGAAGTTGTGTTTATGATTCGG
AAACTGATGACGGTTCAGCAGCAGAAGTGCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTGGAGGAAGAGATGATG
AAGATGGGACAGGAATTGTTGATGGAGTTTTTGGAAATGAAAAAAGGTAGAATTTATGAAAATAAAAAAAATTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18119.46 Da
• Isoelectric Point: 4.3193

>AT44590 WP_024409333.1 NZ_CP002007:1215908-1216384 [Streptococcus suis 05HAS68]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA

Nucleotide

• Length: 477 bp

>AT44590 NZ_CP002007:1215908-1216384 [Streptococcus suis 05HAS68]
ATGATTGGAGATAATATTAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTTGGAATTTC
TCGAAATAGTTTGAGCCGTTATGAAAATGGGACAAGCTCGTTATCAACAGAGCTCATAGACCGTATCTGTCAGAAATTTA
ATGTATCATATGTTGATATTGTAGGAGAAGAAAAAATGTTAACACCAGTGGAAGATTATCAATTAACCTTAAAAATTGAA
GTTATCAAAGAGCGTGGCGCAGCGATTTTGTCCGAACTATATCGCTATCAAGATAGTCAAGGAATTACTTTTGATGATGA
GACTAGCCCTTGGATTTTGATGAGTGATGATTTGTCTGATCTTATCAATACCAAGATTTACCTTGTCAATACTTTTGATG
AAGTGGAGCGTTACAATGGTTATTTAGATGGTATTGAGCGAATGTTGGAGCTTGCTAATCATCAGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z8INM2