Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 839753..840236 Replicon chromosome
Accession NZ_CP002007
Organism Streptococcus suis 05HAS68

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag HAS68_RS04355 Protein ID WP_009910443.1
Coordinates 839976..840236 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag HAS68_RS04350 Protein ID WP_012775256.1
Coordinates 839753..839974 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAS68_RS04320 835931..836371 + 441 WP_024409208.1 hypothetical protein -
HAS68_RS04325 836441..836941 + 501 WP_024409209.1 hypothetical protein -
HAS68_RS04330 837081..837467 + 387 WP_009910450.1 hypothetical protein -
HAS68_RS04335 837651..837833 + 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin -
HAS68_RS04340 837873..838325 + 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin -
HAS68_RS04345 838437..838646 + 210 WP_009910447.1 hypothetical protein -
HAS68_RS04350 839753..839974 + 222 WP_012775256.1 hypothetical protein Antitoxin
HAS68_RS04355 839976..840236 + 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HAS68_RS04360 840403..841044 + 642 WP_002935700.1 HAD family hydrolase -
HAS68_RS04365 841077..841262 - 186 WP_002935693.1 hypothetical protein -
HAS68_RS04370 841326..842330 - 1005 WP_009910438.1 lactonase family protein -
HAS68_RS04375 842466..843632 + 1167 WP_002935690.1 AI-2E family transporter -
HAS68_RS04380 843622..844851 + 1230 WP_009910437.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 830147..841262 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T44589 WP_009910443.1 NZ_CP002007:839976-840236 [Streptococcus suis 05HAS68]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T44589 NZ_CP002007:839976-840236 [Streptococcus suis 05HAS68]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT44589 WP_012775256.1 NZ_CP002007:839753-839974 [Streptococcus suis 05HAS68]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT44589 NZ_CP002007:839753-839974 [Streptococcus suis 05HAS68]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References